Membrane contact sites, ancient and central hubs of cellular lipid logistics

Autor(en): Jain, Amrita
Holthuis, Joost C. M.
Stichwörter: Biochemistry & Molecular Biology; Cell Biology; CERAMIDE TRANSPORT PROTEIN; D-MEDIATED PHOSPHORYLATION; DEPENDENT ACTIVATION; ENDOPLASMIC-RETICULUM; Evolution; Golgi complex; GOLGI-APPARATUS REQUIRES; Lipid transfer protein; MASS-SPECTROMETRY; Mitochondria; OXYSTEROL-BINDING PROTEIN; PLASMA-MEMBRANE; PROTEIN-KINASE-D; Secretory pathway; Sphingolipid biosynthesis; SPONTANEOUS INTERBILAYER TRANSFER
Erscheinungsdatum: 2017
Herausgeber: ELSEVIER SCIENCE BV
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volumen: 1864
Ausgabe: 9, SI
Startseite: 1450
Seitenende: 1458
Zusammenfassung: 
Membrane contact sites (MCSs) are regions where two organelles are closely apposed to facilitate molecular communication and promote a functional integration of compartmentalized cellular processes. There is growing evidence that MCSs play key roles in controlling intracellular lipid flows and distributions. Strikingly, even organelles connected by vesicular trafficking exchange lipids en bulk via lipid transfer proteins that operate at MCSs. Herein, we describe how MCSs developed into central hubs of lipid logistics during the evolution of eukaryotic cells. We then focus on how modern eukaryotes exploit MCSs to help solve a major logistical problem, namely to preserve the unique lipid mixtures of their early and late secretory organelles in the face of extensive vesicular trafficking. This article is part of a Special Issue entitled: Membrane Contact Sites edited by Christian Ungermann and Benoit Kornmann.
ISSN: 01674889
DOI: 10.1016/j.bbamcr.2017.05.017

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