Membrane contact sites, ancient and central hubs of cellular lipid logistics

DC FieldValueLanguage
dc.contributor.authorJain, Amrita
dc.contributor.authorHolthuis, Joost C. M.
dc.date.accessioned2021-12-23T16:12:06Z-
dc.date.available2021-12-23T16:12:06Z-
dc.date.issued2017
dc.identifier.issn01674889
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/10039-
dc.description.abstractMembrane contact sites (MCSs) are regions where two organelles are closely apposed to facilitate molecular communication and promote a functional integration of compartmentalized cellular processes. There is growing evidence that MCSs play key roles in controlling intracellular lipid flows and distributions. Strikingly, even organelles connected by vesicular trafficking exchange lipids en bulk via lipid transfer proteins that operate at MCSs. Herein, we describe how MCSs developed into central hubs of lipid logistics during the evolution of eukaryotic cells. We then focus on how modern eukaryotes exploit MCSs to help solve a major logistical problem, namely to preserve the unique lipid mixtures of their early and late secretory organelles in the face of extensive vesicular trafficking. This article is part of a Special Issue entitled: Membrane Contact Sites edited by Christian Ungermann and Benoit Kornmann.
dc.description.sponsorshipEuropean Union (MC-ITN Sphingonet Project) [289278]; Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [Sonderforschungsbereich 944]; We thank Svenja Bockelmann for comments on the manuscript. Work in our laboratory is funded by the European Union (MC-ITN Sphingonet Project 289278) and the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 944, Project 14).
dc.language.isoen
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
dc.subjectBiochemistry & Molecular Biology
dc.subjectCell Biology
dc.subjectCERAMIDE TRANSPORT PROTEIN
dc.subjectD-MEDIATED PHOSPHORYLATION
dc.subjectDEPENDENT ACTIVATION
dc.subjectENDOPLASMIC-RETICULUM
dc.subjectEvolution
dc.subjectGolgi complex
dc.subjectGOLGI-APPARATUS REQUIRES
dc.subjectLipid transfer protein
dc.subjectMASS-SPECTROMETRY
dc.subjectMitochondria
dc.subjectOXYSTEROL-BINDING PROTEIN
dc.subjectPLASMA-MEMBRANE
dc.subjectPROTEIN-KINASE-D
dc.subjectSecretory pathway
dc.subjectSphingolipid biosynthesis
dc.subjectSPONTANEOUS INTERBILAYER TRANSFER
dc.titleMembrane contact sites, ancient and central hubs of cellular lipid logistics
dc.typejournal article
dc.identifier.doi10.1016/j.bbamcr.2017.05.017
dc.identifier.isiISI:000406571200003
dc.description.volume1864
dc.description.issue9, SI
dc.description.startpage1450
dc.description.endpage1458
dc.contributor.orcid0000-0001-8912-1586
dc.contributor.researcheridAAL-9157-2020
dc.identifier.eissn00063002
dc.publisher.placePO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
dcterms.isPartOf.abbreviationBiochim. Biophys. Acta-Mol. Cell Res.
dcterms.oaStatusBronze
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