Atrial fibrillation is a risk marker for worse in-hospital and long-term outcome in patients with peripheral artery disease

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dc.contributor.authorWasmer, Kristina
dc.contributor.authorUnrath, Michael
dc.contributor.authorKoebe, Julia
dc.contributor.authorMalyar, Nasser M.
dc.contributor.authorFreisinger, Eva
dc.contributor.authorMeyborg, Matthias
dc.contributor.authorBreithardt, Guenter
dc.contributor.authorEckardt, Lars
dc.contributor.authorReinecke, Holger
dc.date.accessioned2021-12-23T16:12:27Z-
dc.date.available2021-12-23T16:12:27Z-
dc.date.issued2015
dc.identifier.issn01675273
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/10219-
dc.description.abstractObjectives: To investigate the relevance of atrial fibrillation or flutter (AF) for outcome of patients who are hospitalized for peripheral artery disease (PAD) and/or critical limb ischemia (CLI). Methods and results: We compared baseline data, co-morbidities, procedural data as well as in-hospital and long-term outcome of 41,882 patients who were hospitalized with PAD or CLI between 2009 and 2011 according to whether they did or did not have atrial fibrillation/flutter. Follow-up was available until December 2012. Of these, 5622 patients (13.4%) had AF. AF patients were significantly older (78 /- 9 vs. 70 /- 11 years) and had significantly more comorbidities, such as diabetes (40.8 vs. 31.1%), chronic kidney disease (40.1 vs. 19.0%), coronary artery disease (38.0 vs. 23.0%) and chronic heart failure (26.9 vs. 7.2%, each p < 0.001). They had more advanced PAD as shown by higher Rutherford classes. In-hospital complications including acute renal failure, myocardial infarction, stroke sepsis and death occurred significantly more often (each p < 0.001). Duration of hospital stay was significantly longer and costs were markedly higher in patients with AF (each p < 0.001). Using multivariate Cox regression analyses regarding long-term outcomes, AF was an independent predictor for death (HRR 1.46; 95% CI 1.39-1.52, p < 0.001), ischemic stroke (HRR 1.63; 95% CI 1.44-1.85) and amputation (HRR 1.14; 95% CI 1.07-1.21). Conclusion: Presence of AF in patients admitted for PAD and CLI is associated with worse in-hospital and long-term outcome than in patients without AF. This effect was independent of numerous other comorbidities and stage of vascular disease. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
dc.language.isoen
dc.publisherELSEVIER IRELAND LTD
dc.relation.ispartofINTERNATIONAL JOURNAL OF CARDIOLOGY
dc.subjectAtrial fibrillation
dc.subjectCardiac & Cardiovascular Systems
dc.subjectCardiovascular System & Cardiology
dc.subjectCORONARY
dc.subjectESC
dc.subjectEURO HEART SURVEY
dc.subjectIMPACT
dc.subjectOutcome
dc.subjectPeripheral artery disease
dc.subjectSTROKE
dc.subjectTHROMBOEMBOLISM
dc.titleAtrial fibrillation is a risk marker for worse in-hospital and long-term outcome in patients with peripheral artery disease
dc.typejournal article
dc.identifier.doi10.1016/j.ijcard.2015.06.094
dc.identifier.isiISI:000361150100048
dc.description.volume199
dc.description.startpage223
dc.description.endpage228
dc.identifier.eissn18741754
dc.publisher.placeELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
dcterms.isPartOf.abbreviationInt. J. Cardiol.
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