1',5'-anhydrohexitol oligonucleotides: Hybridisation and strand displacement with oligoribonucleotides, interaction with RNase H and HIV reverse transcriptase
DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Hendrix, C | |
dc.contributor.author | Rosemeyer, H | |
dc.contributor.author | DeBouvere, B | |
dc.contributor.author | VanAerschot, A | |
dc.contributor.author | Seela, F | |
dc.contributor.author | Herdewijn, P | |
dc.date.accessioned | 2021-12-23T16:12:28Z | - |
dc.date.available | 2021-12-23T16:12:28Z | - |
dc.date.issued | 1997 | |
dc.identifier.issn | 09476539 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/10234 | - |
dc.description.abstract | Hexitol nucleic acids (HNAs) with four natural bases form stable and sequence-selective duplexes with RNA. This was investigated by T-m determinations and gel shift experiments. The CD spectra of an HNA-RNA duplex show similarities with the CD spectra of the A-form of dsRNA. Single-stranded HNAs are able to induce strand displacement in a double-stranded RNA sequence. An HNA-RNA duplex is a poor substrate for RNase H, and can inhibit the RNase H-mediated cleavage of a natural DNA-RNA substrate. The HNA-RNA hybrid enhances the activity of HIV reverse transcriptase. | |
dc.language.iso | en | |
dc.publisher | WILEY-V C H VERLAG GMBH | |
dc.relation.ispartof | CHEMISTRY-A EUROPEAN JOURNAL | |
dc.subject | Chemistry | |
dc.subject | Chemistry, Multidisciplinary | |
dc.subject | duplex | |
dc.subject | gel mobility | |
dc.subject | nucleic acids | |
dc.subject | NUCLEIC-ACIDS | |
dc.subject | NUCLEOSIDES | |
dc.subject | oligonucleotides | |
dc.subject | strand displacement | |
dc.title | 1',5'-anhydrohexitol oligonucleotides: Hybridisation and strand displacement with oligoribonucleotides, interaction with RNase H and HIV reverse transcriptase | |
dc.type | journal article | |
dc.identifier.doi | 10.1002/chem.19970030920 | |
dc.identifier.isi | ISI:A1997XX29700017 | |
dc.description.volume | 3 | |
dc.description.issue | 9 | |
dc.description.startpage | 1513 | |
dc.description.endpage | 1520 | |
dc.contributor.orcid | 0000-0003-3589-8503 | |
dc.contributor.orcid | 0000-0003-3528-8588 | |
dc.identifier.eissn | 15213765 | |
dc.publisher.place | BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY | |
dcterms.isPartOf.abbreviation | Chem.-Eur. J. | |
crisitem.author.dept | Institut für Chemie neuer Materialien | - |
crisitem.author.deptid | institute11 | - |
crisitem.author.parentorg | FB 05 - Biologie/Chemie | - |
crisitem.author.grandparentorg | Universität Osnabrück | - |
crisitem.author.netid | RoHe783 | - |
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