Malignant atrophic papulosis (Kohlmeier-Degos disease). Failure to respond to interferon alpha-2a, pentoxifylline and aspirin

Autor(en): Melnik, B
Hariry, H
Vakilzadeh, F
Gropp, C
Sitzer, G
Stichwörter: aspirin; Dermatology; FAMILY; interferon alpha-2a; Kohlmeier-Degos disease; malignant atrophic papulosis; pentoxifylline
Erscheinungsdatum: 2002
Herausgeber: SPRINGER
Volumen: 53
Ausgabe: 9
Startseite: 618
Seitenende: 621
A 45 year old female patient presented with the cutaneous manifestations of malignant atrophic papulosis (Kohlmeier-Degos disease) for two years. The typical papules with central porcelain-white atrophy correspond histologically to wedge-shaped necrosis of the connective tissue due to thrombotic occlusion of small vessels in the corium. The pathogenesis of malignant atrophic papulosis and effective treatment modalities are unknown. A slow virus infection has been suggested by some authors. Therefore, we attempted an immune therapy with interferon alpha-2a over a period of 11 months, but failed to cause a significant effect on the appearance and progression of the skin lesions. Furthermore, we could not confirm the effectiveness of a recently reported treatment modality with pentoxifylline and aspirin administered to our patient over a period of 5 months.
ISSN: 00178470
DOI: 10.1007/s00105-002-0347-7

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