Robust silver-mediated imidazolo-dC base pairs in metal DNA: dinuclear silver bridges with exceptional stability in double helices with parallel and antiparallel strand orientation

Autor(en): Jana, Sunit Kumar
Guo, Xiurong
Mei, Hui
Seela, Frank
Stichwörter: ANALOGS; Chemistry; Chemistry, Multidisciplinary; CYTOSINE; ION-BINDING; MISMATCH; NUCLEOBASES; NUCLEOSIDES; OLIGONUCLEOTIDE DUPLEXES; RESIDUES; RNA; TAUTOMERISM
Erscheinungsdatum: 2015
Herausgeber: ROYAL SOC CHEMISTRY
Journal: CHEMICAL COMMUNICATIONS
Volumen: 51
Ausgabe: 97
Startseite: 17301
Seitenende: 17304
Zusammenfassung: 
A new unprecedented metal-mediated base pair was designed that stabilizes reverse Watson-Crick DNA (parallel strand orientation, ps) as well as canonical Watson-Crick DNA (antiparallel strand orientation, aps). This base pair contains two imidazolo-dC units decorated with furan residues. T-m, measurements and spectroscopic studies reveal that each silver-mediated furano-imidazolo-dC forms exceptionally stable duplexes with ps and aps chain orientation. This stability increase by a silver-mediated base pair is the highest reported so far for ps and aps DNA helices.
ISSN: 13597345
DOI: 10.1039/c5cc06734k

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