No remarkable differences in rates of sensitization to common type I and IV allergens between FLG loss-of-function mutation carriers and wild-type subjects
Autor(en): | Landeck, Lilla Visser, Maaike Skudlik, Christoph Brans, Richard Kezic, Sanja John, Swen Malte |
Stichwörter: | allergens; Allergy; contact dermatitis; Dermatology; DISEASE; ECZEMA; filaggrin gene; FILAGGRIN NULL MUTATIONS; GENERAL-POPULATION; IRRITANT CONTACT-DERMATITIS; loss-of-function mutations; METAANALYSIS; NICKEL; patch test; PREDISPOSE; prick test; RISK; SEVERE ATOPIC-DERMATITIS | Erscheinungsdatum: | 2014 | Herausgeber: | WILEY-BLACKWELL | Journal: | CONTACT DERMATITIS | Volumen: | 70 | Ausgabe: | 1 | Startseite: | 27 | Seitenende: | 34 | Zusammenfassung: | BackgroundLoss-of-function mutations in the filaggrin gene (FLG) have been associated with reduced skin barrier function, possibly allowing increased penetration of irritants and allergens. ObjectivesTo study whether FLG loss-of-function mutation carriers show different rates of sensitization to common type I and IV allergens among patients referred for occupational contact dermatitis of the hands. Materials and MethodsFour hundred and ninety-six Caucasian patients were genotyped for four FLG null mutations and patch tested with the European baseline series. In addition, 431 patients underwent prick testing with common type I allergens. ResultsOverall, 67 patients showed a heterozygous mutation in the FLG alleles R501X, R2447X, S3247X, and/or 2282del4. Sensitization rates for type I allergens from a European prick test series did not show significant differences between FLG loss-of-function mutation carriers and wild-type subjects. For type IV allergens, significantly more FLG loss-of-function carriers were found to be sensitized to lanolin and p-tert-butylphenol-formaldehyde resin. ConclusionsProbably a variety of immunological mechanisms other than that resulting from the filaggrin system have an impact on allergic sensitization to a greater degree. Larger cohorts may be necessary to increase the statistical power of the findings presented regarding type I and IV sensitization. |
ISSN: | 01051873 | DOI: | 10.1111/cod.12109 |
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geprüft am 17.05.2024