Design, synthesis, and biological evaluation of novel analogues of archazolid: A highly potent simplified V-ATPase inhibitor
| Autor(en): | Menche, Dirk Hassfeld, Jorma Sasse, Florenz Huss, Markus Wieczorek, Helmut |
Stichwörter: | analogues; ARCHANGIUM-GEPHYRA; archazolid; Chemistry; Chemistry, Medicinal; Chemistry, Organic; H+-ATPASE; MEMBRANE; modeling; MOLECULAR MECHANICS; Pharmacology & Pharmacy; structure-activity data; SUBUNIT; V-ATPase; VACUOLAR-TYPE ATPASE | Erscheinungsdatum: | 2007 | Herausgeber: | PERGAMON-ELSEVIER SCIENCE LTD | Journal: | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | Volumen: | 17 | Ausgabe: | 6 | Startseite: | 1732 | Seitenende: | 1735 | Zusammenfassung: | Novel analogues of the V-ATPase inhibitors archazolid A and B with modifications of the free hydroxyl groups and the side chain were designed by molecular modeling, synthesized by derivatization of the parent natural product and evaluated for V-ATPase inhibition and growth inhibition of murine connective tissue cells. (c) 2006 Elsevier Ltd. All rights reserved. |
ISSN: | 0960894X | DOI: | 10.1016/j.bmcl.2006.12.073 |
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