Nucleobase-Functionalized 5-Aza-7-deazaguanine Ribo- and 2 `-Deoxyribonucleosides: Glycosylation, Pd-Assisted Cross-Coupling, and Photophysical Properties

Autor(en): Leonard, Peter
Kondhare, Dasharath
Jentgens, Xenia
Daniliuc, Constantin
Seela, Frank
Stichwörter: 5-AZA-7-DEAZA-2'-DEOXYGUANOSINE; 7-DEAZA-2'-DEOXYADENOSINES; 7-DEAZAPURINE; BASE-PAIR; Chemistry; Chemistry, Organic; ELECTRON-TRANSFER; FLUORESCENT DNA; NUCLEOSIDE ANALOGS; NUCLEOTIDES; PROBES; PYRENE
Erscheinungsdatum: 2019
Herausgeber: AMER CHEMICAL SOC
Journal: JOURNAL OF ORGANIC CHEMISTRY
Volumen: 84
Ausgabe: 21
Startseite: 13313
Seitenende: 13328
Zusammenfassung: 
The special nucleobase recognition pattern of S-aza-7-deazaguanine nucleosides makes them valuable for construction of homo purine DNA, silver-mediated base pairs, and expansion of the four letter genetic coding system. To widen the utility of 5-aza-7-deazaguanine nucleosides, side chains were introduced at position-7 of the nucleobase. As key compounds, 7-iodo nucleosides were synthesized. Nucleobase anion glycosylation of the iodo derivative of isobutyrylated S-aza-7-deazaguanine with the bromo sugar of 2,3,S-tri-O-benzoyl-1-O-acetyl-D-ribofuranose gave the pure beta-D anomeric N-9 glycosylation product (67%), whereas one-pot Vorbriiggen conditions gave only 42% of the iodinated nucleoside. The noniodinated nucleoside was formed in 84%. For the synthesis of 2'-deoxyribonucleosides, anion glycosylation performed with Hoffer's 2'-deoxyhalogenose yielded an anomeric mixture (a-D = 33% and beta-D = 39%) of 2'-deoxyribonucleosides. Various side chain derivatives were prepared from nonprotected nucleosides by Pd-assisted Sonogashira or Suzuki-Miyaura cross-coupling. Among the functionalized ribonucleosides and anomeric 2'-deoxyribonucleosides, some of them showed strong fluorescence. Benzofuran and pyrene derivatives display high quantum yields in non-aqueous solvents and solvatochromism. Single-crystal X-ray analysis of 7-iodo-5-aza-7-deaza-2'-deoxyguanosine displayed intermolecular iodo-oxygen interactions in the crystal and channels filled with solvent molecules.
ISSN: 00223263
DOI: 10.1021/acs.joc.9b01347

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