The organization of metabolic reaction networks. III. Application for diauxic growth on glucose and lactose

DC FieldValueLanguage
dc.contributor.authorKremling, A
dc.contributor.authorBettenbrock, K
dc.contributor.authorLaube, B
dc.contributor.authorJahreis, K
dc.contributor.authorLengeler, JW
dc.contributor.authorGilles, ED
dc.date.accessioned2021-12-23T16:13:42Z-
dc.date.available2021-12-23T16:13:42Z-
dc.date.issued2001
dc.identifier.issn10967176
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/10704-
dc.description.abstractA mathematical model to describe carbon catabolite repression in Escherichia coli is developed and in part validated. The model is aggregated from two functional units describing glucose and lactose transport and degradation. Both units are members of the erp modulon and are under control of a global signal transduction system which calculates the signals that turn on or off gene expression for the specific enzymes. Using isogenic mutant strains, our model is validated by a set of experiments. In these experiments, substrate composition of the preculture and of the experimental culture are varied in order to stimulate the system in different ways. With the obtained measurements (three states in the liquid phase and one intracellular component) a part of the model parameters could be estimated. Therefore all experiments could be sufficiently described with a single set of parameters. (C) 2001 Academic Press.
dc.language.isoen
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartofMETABOLIC ENGINEERING
dc.subjectADENYLATE-CYCLASE
dc.subjectBiotechnology & Applied Microbiology
dc.subjectCATABOLITE REPRESSION
dc.subjectESCHERICHIA-COLI
dc.subjectGENETICALLY STRUCTURED MODELS
dc.subjectLAC OPERON
dc.subjectMULTICOPY PLASMIDS
dc.subjectPROMOTER-OPERATOR FUNCTION
dc.subjectRECEPTOR PROTEIN
dc.subjectSALMONELLA-TYPHIMURIUM
dc.subjectSUGAR PHOSPHOTRANSFERASE SYSTEM
dc.titleThe organization of metabolic reaction networks. III. Application for diauxic growth on glucose and lactose
dc.typejournal article
dc.identifier.doi10.1006/mben.2001.0199
dc.identifier.isiISI:000173717100007
dc.description.volume3
dc.description.issue4
dc.description.startpage362
dc.description.endpage379
dc.contributor.researcheridAAN-5812-2020
dc.publisher.place525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
dcterms.isPartOf.abbreviationMetab. Eng.
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