IL1A-889 C/T gene polymorphism in irritant contact dermatitis

Abstract

Background Upon skin contact to irritants, interleukin-1 alpha (IL-1) is released in the stratum corneum as a primary step of skin inflammation. Variations in the IL-1A gene have been shown to alter the expression of IL-1. This may influence the susceptibility to skin inflammation and the development of irritant contact dermatitis (ICD). Objective To determine effects of an IL1A-889 C/T polymorphism in view of susceptibility to develop irritant contact dermatitis. Methods In a case-control study, 478 Caucasian patients with occupational ICD of the hands were genotyped for an IL1A-889 C/T polymorphism. Results were compared to 393 apprentices from the same high risk occupations (controls). Results Trends of a protective effect of the CT transition at position IL1A-889 were seen (OR=0.81; 95% CI: 0.65-1.00). The genotype distribution for IL1A-889 was 52.2% wild type (C/C), 39.2% heterozygous (C/T) and 8.6% homozygous for variant allele (T/T) in patients and 46.0%, 42.7% and 11.4% in controls. Subgroup analysis, which took into account atopy status and exposure, did not reveal a significant effect of this polymorphism for an aberrant risk to acquire for ICD. Conclusion Our study indicates a possible protective effect of the IL1A-889 C/T polymorphism regarding the development of ICD.