A Dimer to Bridge Early Autophagosomal Membranes

Autor(en): Reggiori, Fulvio
Ungermann, Christian 
Stichwörter: ATG PROTEINS; Biochemistry & Molecular Biology; Cell Biology; KINASE; ORGANIZATION
Erscheinungsdatum: 2012
Herausgeber: CELL PRESS
Journal: CELL
Volumen: 151
Ausgabe: 7
Startseite: 1403
Seitenende: 1405
Zusammenfassung: 
The Atg1/ULK complex plays a key role in the early stages of autophagosome assembly. In this issue, Ragusa et al. reveal the molecular basis for some interactions within this complex, finding that the crescent-shaped Atg17 dimer is critical for autophagy, whereas Atg1 may have the ability to cluster membranes.
ISSN: 00928674
DOI: 10.1016/j.cell.2012.12.008

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