A Dimer to Bridge Early Autophagosomal Membranes
| Autor(en): | Reggiori, Fulvio Ungermann, Christian |
Stichwörter: | ATG PROTEINS; Biochemistry & Molecular Biology; Cell Biology; KINASE; ORGANIZATION | Erscheinungsdatum: | 2012 | Herausgeber: | CELL PRESS | Enthalten in: | CELL | Band: | 151 | Ausgabe: | 7 | Startseite: | 1403 | Seitenende: | 1405 | Zusammenfassung: | The Atg1/ULK complex plays a key role in the early stages of autophagosome assembly. In this issue, Ragusa et al. reveal the molecular basis for some interactions within this complex, finding that the crescent-shaped Atg17 dimer is critical for autophagy, whereas Atg1 may have the ability to cluster membranes. |
ISSN: | 00928674 | DOI: | 10.1016/j.cell.2012.12.008 |
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