Cruentaren, a new antifungal salicylate-type macrolide from Byssovorax cruenta (Myxobacteria) with inhibitory effect on mitochondrial ATPase activity - Fermentation and biological properties
| Autor(en): | Kunze, Brigitte Steinmetz, Heinrich Hoefle, Gerhard Huss, Markus Wieczorek, Helmut Reichenbach, Hans |
Stichwörter: | ATPase; benzolactone class antifungal; Biotechnology & Applied Microbiology; CHONDROMYCES-CROCATUS MYXOBACTERIA; cruentaren; cytotoxic; CYTOTOXIC MACROLIDES; F0F1; Immunology; MARINE SPONGE; Microbiology; myxobacteria; Pharmacology & Pharmacy; SPECIES MYXOBACTERIA | Erscheinungsdatum: | 2006 | Herausgeber: | NATURE PUBLISHING GROUP | Journal: | JOURNAL OF ANTIBIOTICS | Volumen: | 59 | Ausgabe: | 10 | Startseite: | 664 | Seitenende: | 668 | Zusammenfassung: | The novel macrolide cruentaren A was produced at levels up to 3.2 mg/liter by cultures of the myxobacterium Byssovorax cruenta. The new compound strongly inhibited the growth of yeasts and filamentous fungi and showed high cytotoxicity against L929 mouse fibroblast cells. A minor co-metabolite of cruentaren A, named cruentaren B, and identified as a six-membered lactone isomer of cruentaren A, showed only marginal cytotoxicity and no antifungal activity. Cruentaren A inhibited F0F1 mitochondrial ATP-hydrolysis in submitochondrial particles of yeasts and beef heart. |
ISSN: | 00218820 | DOI: | 10.1038/ja.2006.89 |
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geprüft am 17.05.2024
