Bacterial Unculturability and the Formation of Intercellular Metabolic Networks
DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Pande, Samay | |
dc.contributor.author | Kost, Christian | |
dc.date.accessioned | 2021-12-23T16:14:34Z | - |
dc.date.available | 2021-12-23T16:14:34Z | - |
dc.date.issued | 2017 | |
dc.identifier.issn | 0966842X | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/11137 | - |
dc.description.abstract | The majority of known bacterial species cannot be cultivated under laboratory conditions. Here we argue that the adaptive emergence of obligate metabolic interactions in natural bacterial communities can explain this pattern. Bacteria commonly release metabolites into the external environment. Accumulating pools of extracellular metabolites create an ecological niche that benefits auxotrophic mutants, which have lost the ability to autonomously produce the corresponding metabolites. In addition to a diffusion-based metabolite transfer, auxotrophic cells can use contact-dependent means to obtain nutrients from other co-occurring cells. Spatial colocalisation and a continuous coevolution further increase the nutritional dependency and optimise fluxes through combined metabolic networks. Thus, bacteria likely function as networks of interacting cells that reciprocally exchange nutrients and biochemical functions rather than as physiologically autonomous units. | |
dc.description.sponsorship | Volkswagen FoundationVolkswagen [I/85 290]; Max-Planck SocietyMax Planck Society; Jena School of Microbial Communication; ETH Marie Curie COFUND Fellowship; German Research FoundationGerman Research Foundation (DFG) [SFB 944/2-2016]; The authors would like to thank the whole EEE group, Christoph Kaleta, Paul Rainey, and Will Ratcliff for helpful discussions, Sigal Ben-Yehuda for sharing Figure 4A, as well as Wilhelm Boland for support. This work was funded by the Volkswagen Foundation (CK, I/85 290), the Max-Planck Society (CK), the Jena School of Microbial Communication (CK, SP, JSMC), and ETH Marie Curie COFUND Fellowship (SP) as well as the German Research Foundation (CK, SFB 944/2-2016). | |
dc.language.iso | en | |
dc.publisher | ELSEVIER SCI LTD | |
dc.relation.ispartof | TRENDS IN MICROBIOLOGY | |
dc.subject | Biochemistry & Molecular Biology | |
dc.subject | COOPERATION | |
dc.subject | DIVERSITY | |
dc.subject | ESCHERICHIA-COLI | |
dc.subject | GLUTAMIC ACID | |
dc.subject | GROWTH | |
dc.subject | MICROBIAL EVOLUTION | |
dc.subject | Microbiology | |
dc.subject | MICROORGANISMS | |
dc.subject | NICHE-CONSTRUCTION | |
dc.subject | OXIDIZING BACTERIA | |
dc.subject | SYMBIOBACTERIUM-THERMOPHILUM | |
dc.title | Bacterial Unculturability and the Formation of Intercellular Metabolic Networks | |
dc.type | review | |
dc.identifier.doi | 10.1016/j.tim.2017.02.015 | |
dc.identifier.isi | ISI:000399286000006 | |
dc.description.volume | 25 | |
dc.description.issue | 5 | |
dc.description.startpage | 349 | |
dc.description.endpage | 361 | |
dc.contributor.orcid | 0000-0002-7870-7343 | |
dc.contributor.orcid | 0000-0002-4897-3923 | |
dc.contributor.researcherid | N-1553-2014 | |
dc.identifier.eissn | 18784380 | |
dc.publisher.place | THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND | |
dcterms.isPartOf.abbreviation | Trends Microbiol. | |
crisitem.author.dept | FB 05 - Biologie/Chemie | - |
crisitem.author.deptid | fb05 | - |
crisitem.author.orcid | 0000-0002-7870-7343 | - |
crisitem.author.parentorg | Universität Osnabrück | - |
crisitem.author.netid | KoCh846 | - |
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geprüft am 06.06.2024