Supramolecular Isoguanosine Assemblies Form Hydrogels with Excellent Long-Term Stability
Autor(en): | Zhao, Hang Schaefer, Andreas H. Seela, Frank |
Stichwörter: | ANALOGS; Chemistry; Chemistry, Multidisciplinary; DUPLEX DNA; GUANINE; HELIX FORMATION; hydrogels; ISOGUANINE; isoguanosine; NUCLEOSIDES; NUCLEOTIDES; OLIGONUCLEOTIDES; PHOTOCHEMICAL-SYNTHESIS; QUARTETS; selfassembly; supramolecular chemistry | Erscheinungsdatum: | 2017 | Herausgeber: | WILEY-V C H VERLAG GMBH | Journal: | CHEMPLUSCHEM | Volumen: | 82 | Ausgabe: | 6 | Startseite: | 826 | Seitenende: | 833 | Zusammenfassung: | Supramolecular nucleoside-based hydrogels have the potential to be utilized in drug delivery, regenerative medicine and for the construction of nanoscopic devices. Isoguanosine, its 2'-deoxyribonucleoside and the 2'-deoxy-2'-fluororibonucleoside form hydrogels in alkali metal salt solutions. Gel stability depends on the metal ions used (Li+, Na+, K+, Rb+, Cs+). All isoguanosine gels show long-term stability of several months, whereas guanosine gels collapse within minutes or hours. Rheological data confirm a 15 times higher hydrogel stability for isoguanosine compared to guanosine. Isoguanosine gel stability covers a broad pH range (pH 3-10), and the stability at physiological Na+ ion concentration is striking. SEM images reveal that isoguanosine self-assembles into helical stacked fibers that are interconnected whereas guanosine forms discrete ribbons. Moreover, isoguanosine gels display excellent loading and release ability for small molecules. |
ISSN: | 21926506 | DOI: | 10.1002/cplu.201600586 |
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