(-)-Deprenyl alleviates the degenerative changes induced in the neonatal rat spinal cord by CSF from amyotrophic lateral sclerosis patients

DC FieldValueLanguage
dc.contributor.authorShahani, N
dc.contributor.authorGourie-Devi, M
dc.contributor.authorNalini, A
dc.contributor.authorRammohan, PY
dc.contributor.authorShobha, K
dc.contributor.authorHarsha, HN
dc.contributor.authorRaju, TR
dc.date.accessioned2021-12-23T16:15:48Z-
dc.date.available2021-12-23T16:15:48Z-
dc.date.issued2004
dc.identifier.issn17482968
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/11590-
dc.description.abstractPrevious studies from our laboratory suggest the presence of toxic factor(s) in the cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS) which induces degenerative changes in the spinal cord neurons. The present work was carried out to investigate the role of (-)-deprenyl in attenuating these degenerative changes. CSF samples from ALS and non-ALS neurological patients were injected into the spinal subarachnoid space of 3-day-old rat pups, followed by a single dose (0.01 mg/kg body weight) of (-)- deprenyl, administered 24 h after CSF injection. After a further period of 24 h, the rats were sacrificed and the spinal cord sections were stained with antibodies against phosphorylated neurofilament (NF, SMI-31 antibody) and glial fibrillary acidic protein (GFAP). Activity of lactate dehydrogenase (LDH) was also measured. (-)-Deprenyl injection resulted in a significant (61%) decrease in the number of SMI-31 stained neuronal soma in the ventral horn of the spinal cord of ALS CSF exposed rats. This was accompanied by a reduction in the astrocytes immunoreactive for GFAP. There was also a significant (35%) decrease in the LDH activity following (-)- deprenyl treatment. These results suggest that (-)- deprenyl may confer neuroprotection against the toxic factor(s) present in ALS CSF.
dc.language.isoen
dc.publisherINFORMA HEALTHCARE
dc.relation.ispartofAMYOTROPHIC LATERAL SCLEROSIS
dc.subject(-)-deprenyl
dc.subjectALZHEIMERS-DISEASE
dc.subjectamyotrophic lateral sclerosis
dc.subjectastrocytes
dc.subjectCEREBROSPINAL-FLUID
dc.subjectClinical Neurology
dc.subjectFACIAL MOTONEURONS
dc.subjectGENE-EXPRESSION
dc.subjectL-DEPRENYL
dc.subjectmotor neurons
dc.subjectMOTOR-NEURON DEGENERATION
dc.subjectneonatal rats
dc.subjectNEUROFILAMENT PHOSPHORYLATION
dc.subjectNeurosciences & Neurology
dc.subjectNIGRAL NEURONS
dc.subjectOXIDASE-B-INHIBITORS
dc.subjectTIME-COURSE
dc.title(-)-Deprenyl alleviates the degenerative changes induced in the neonatal rat spinal cord by CSF from amyotrophic lateral sclerosis patients
dc.typejournal article
dc.identifier.doi10.1080/14660820410017037
dc.identifier.isiISI:000224050300007
dc.description.volume5
dc.description.issue3
dc.description.startpage172
dc.description.endpage179
dc.contributor.orcid0000-0003-3400-4395
dc.contributor.orcid0000-0001-9791-3639
dc.contributor.researcheridABE-2908-2020
dc.contributor.researcheridI-1564-2015
dc.contributor.researcheridAAT-2469-2021
dc.identifier.eissn1471180X
dc.publisher.placeTELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
dcterms.isPartOf.abbreviationAmyotroph. Lateral. Scler.
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