Prefrontal Theta Oscillations Are Modulated by Estradiol Status During Fear Recall and Extinction Recall

DC FieldValueLanguage
dc.contributor.authorBierwirth, Philipp
dc.contributor.authorSperl, Matthias F. J.
dc.contributor.authorAntov, Martin I.
dc.contributor.authorStockhorst, Ursula
dc.date.accessioned2021-12-23T16:16:23Z-
dc.date.available2021-12-23T16:16:23Z-
dc.date.issued2021
dc.identifier.issn24519022
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/11849-
dc.description.abstractBACKGROUND: Emerging human studies demonstrate that theta oscillations in the dorsal anterior cingulate cortex are enhanced during fear recall (enhanced fear expression) and reduced during successful extinction recall (reduced fear expression). Although evidence suggests sex differences in fear recall and extinction recall, there are currently no human studies examining the oscillatory foundations of these memory processes separately in men and women. METHODS: Because previous studies suggest that estradiol partially mediates these sex differences, we examined 20 men (low estradiol and low progesterone), 20 women using oral contraceptives (low estradiol and low progesterone), and 20 free-cycling women during midcycle (high estradiol and low progesterone). We used a fear conditioning procedure, allowing us to separately assess fear recall and extinction recall 24 hours after fear and extinction learning. Skin conductance responses and electroencephalography were recorded during fear recall and extinction recall, and prefrontal oscillations were source localized. RESULTS: We found elevated fear expression during fear recall and impaired extinction recall, as indicated by increased peripheral arousal (skin conductance responses) and fronto-central theta oscillations, source localized in the dorsal anterior cingulate cortex and dorsomedial prefrontal cortex. Importantly, peripheral arousal and dorsal anterior cingulate cortex theta oscillations were stronger in men and women on oral contraceptives than in women from the midcycle group. CONCLUSIONS: Our data show that neural oscillatory and peripheral correlates of heightened fear expression during fear recall and (impaired) extinction recall do not simply differ between sexes but depend on hormonal fluctuations within women.
dc.language.isoen
dc.publisherELSEVIER
dc.relation.ispartofBIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
dc.subjectAMYGDALA
dc.subjectBLOCKADE
dc.subjectCIRCUITS
dc.subjectCORTEX
dc.subjectEEG
dc.subjectNeurosciences
dc.subjectNeurosciences & Neurology
dc.titlePrefrontal Theta Oscillations Are Modulated by Estradiol Status During Fear Recall and Extinction Recall
dc.typejournal article
dc.identifier.doi10.1016/j.bpsc.2021.02.011
dc.identifier.isiISI:000717953300008
dc.description.volume6
dc.description.issue11
dc.description.startpage1071
dc.description.endpage1080
dc.contributor.orcid0000-0003-3760-5292
dc.contributor.orcid0000-0002-5011-0780
dc.contributor.orcid0000-0002-8420-6481
dc.contributor.researcheridAAF-8411-2020
dc.identifier.eissn24519030
dc.publisher.placeRADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
dcterms.isPartOf.abbreviationBiol. Psychiat.-Cogn. Neurosci. Neuroimag.
dcterms.oaStatushybrid
crisitem.author.deptFB 08 - Humanwissenschaften-
crisitem.author.deptidfb08-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.netidStUr167-
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