Post-stroke depression and functional impairments - A 3-year prospective study

DC FieldValueLanguage
dc.contributor.authorSchoettke, Henning
dc.contributor.authorGerke, Leonie
dc.contributor.authorDuesing, Rainer
dc.contributor.authorMoellmann, Anne
dc.date.accessioned2021-12-23T16:16:23Z-
dc.date.available2021-12-23T16:16:23Z-
dc.date.issued2020
dc.identifier.issn0010440X
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/11851-
dc.description.abstractBackground: Post-Stroke Depression (PSD) is a severe condition, affecting about 30% of stroke survivors within a live-year period after stroke. Post-stroke functional impairments (Fl) and social support are associated with PSD. It is inconclusive, whether one of the factors, post-stroke Fl and PSD, shows a stronger predictive value on the respective other over time. The aims of the present study were to 1) investigate the relationship between PSD, FL and social support of stroke patients in a 3-year prospective design, and 2) address methodological shortcomings of previous studies. Methods: We investigated 174 stroke survivors and assessed PSD with a structured clinical interview and a dimensional symptom rating scale. We conducted regression analyses and applied the approach of multiple imputations (MI) for missing data due to dropout during follow-up. Results: PSD prevalence was 32.2% in the acute phase after stroke. Individuals with a PSD in this phase revealed a fivefold higher risk for PSD 3 years later. Fl in the acute phase did not additionally contribute to the prediction of PSD at follow-up. Compared to individuals without PSD in the acute phase, individuals with PSD had an increased risk for Fl at follow-up. Limitations regarding sample characteristics, design, and dropout are discussed. Conclusions: Results indicate that PSD rather than Fl represents a crucial risk factor for negative long-term consequences regarding physical and psychological health after stroke. Post-stroke treatment might be optimized by a routine assessment of PSD and Fl after stroke and considering the results for personalized treatment options. (C) 2020 The Author(s). Published by Elsevier Inc.
dc.language.isoen
dc.publisherW B SAUNDERS CO-ELSEVIER INC
dc.relation.ispartofCOMPREHENSIVE PSYCHIATRY
dc.subjectDISABILITY
dc.subjectFunctional impairments
dc.subjectHISTORY
dc.subjectIMPACT
dc.subjectMETAANALYSIS
dc.subjectMISSING DATA
dc.subjectPost-stroke depression
dc.subjectPREDICTORS
dc.subjectProspective design
dc.subjectPsychiatry
dc.subjectSCIENTIFIC STATEMENT
dc.subjectSOCIAL SUPPORT
dc.subjectSTROKE
dc.subjectSYMPTOMS
dc.titlePost-stroke depression and functional impairments - A 3-year prospective study
dc.typejournal article
dc.identifier.doi10.1016/j.comppsych.2020.152171
dc.identifier.isiISI:000530709000004
dc.description.volume99
dc.contributor.orcid0000-0003-0439-8258
dc.contributor.orcid0000-0002-4118-9968
dc.contributor.orcid0000-0003-0049-0217
dc.contributor.orcid0000-0003-4767-1349
dc.identifier.eissn15328384
dc.publisher.place1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
dcterms.isPartOf.abbreviationCompr. Psychiat.
dcterms.oaStatusGreen Published, gold
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