2-CHLORO-2'-DEOXYADENOSINE - SYNTHESIS AND ANTILEUKEMIC ACTIVITY OF 8-SUBSTITUTED DERIVATIVES

Abstract

A series of 8-substituted 2-chloro-2'-deoxyadenosine (2-CdA, 1) derivatives were prepared as potential anticancer agents. They were synthesized stereoselectively by the anion displacement reactions on 8-bromo-2-chloro-2'-deoxyadenosine (3). Within the 8-substituted CdA derivatives the 8-thioxo compound 11 was cytotoxic to several leukemia cell lines.