Metabolic adaptation of intracellular bacteria and fungi to macrophages
Autor(en): | Sprenger, Marcel Kasper, Lydia Hensel, Michael Hube, Bernhard |
Stichwörter: | CANDIDA-ALBICANS; CRYPTOCOCCUS-NEOFORMANS; GENE-EXPRESSION; HISTOPLASMA-CAPSULATUM; IMMUNE EVASION STRATEGIES; Intracellular lifestyle; Intracellular nutrient acquisition; LEGIONELLA-PNEUMOPHILA; LISTERIA-MONOCYTOGENES; Metabolic prediction; Microbiology; MYCOBACTERIUM-TUBERCULOSIS; Nutrient restriction; Nutritional immunity; Nutritional virulence; SALMONELLA-TYPHIMURIUM; TRANSCRIPTIONAL RESPONSE; Virology | Erscheinungsdatum: | 2018 | Herausgeber: | ELSEVIER GMBH | Journal: | INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | Volumen: | 308 | Ausgabe: | 1 | Startseite: | 215 | Seitenende: | 227 | Zusammenfassung: | The mature phagosome of macrophages is a hostile environment for the vast majority of phagocytosed microbes. In addition to active destruction of the engulfed microbes by antimicrobial compounds, restriction of essential nutrients in the phagosomal compartment contributes to microbial growth inhibition and killing. However, some pathogenic microorganisms have not only developed various strategies to efficiently withstand or counteract antimicrobial activities, but also to acquire nutrients within macrophages for intracellular replication. Successful intracellular pathogens are able to utilize host-derived amino acids, carbohydrates and lipids as well as trace metals and vitamins during intracellular growth. This requires sophisticated strategies such as phagosome modification or escape, efficient nutrient transporters and metabolic adaptation. In this review, we discuss the metabolic adaptation of facultative intracellular bacteria and fungi to the intracellular lifestyle inside macrophages. |
ISSN: | 14384221 | DOI: | 10.1016/j.ijmm.2017.11.001 |
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geprüft am 20.05.2024