Synthesis, structure and cytotoxicity of a series of Dioxidomolybdenum(VI) complexes featuring Salan ligands

DC FieldValueLanguage
dc.contributor.authorRoy, Satabdi
dc.contributor.authorMohanty, Monalisa
dc.contributor.authorPasayat, Sagarika
dc.contributor.authorMajumder, Sudarshana
dc.contributor.authorSenthilguru, Kulanthaivel
dc.contributor.authorBanerjee, Indranil
dc.contributor.authorReichelt, Martin
dc.contributor.authorReuter, Hans
dc.contributor.authorSinn, Ekkehard
dc.contributor.authorDinda, Rupam
dc.date.accessioned2021-12-23T16:17:50Z-
dc.date.available2021-12-23T16:17:50Z-
dc.date.issued2017
dc.identifier.issn01620134
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/12427-
dc.description.abstractSeven hexacoordinated cis-dioxidomolybdenum(VI) complexes [MoO2L1-7] (1-7) derived from various tetra dentate diamino bis(phenolato) ``salan'' ligands, N,N'-dimethyl-N,N'-bis-(2-hydroxy-3-X-5-Y-6-Z-benzyl)-1,2-diaminoethane {(X = Br, Y = Me, Z = H (H2L1); X = Me, Y=Cl, Z = H (H2L2); X = Pr-i, Y = Cl, Z = Me (H2L3)} and N,N'-bis-(2-hydroxy-3-X-5-Y-6-Z-benzyl)-1,2-diaminopropane {(X = Y = Bu-t, Z = H (H2L4); X = Y = Me, Z = H (H2L5); X = Pr-i, Z = Me (H2L6); X = Y = Br, Z = H (H2L7)} containing O--N donor atoms, have been isolated and structurally characterized. The formation of cis-dioxidomolybdenum(VI) complexes was confirmed by elemental analysis, IR, UV vis and NMR spectroscopy, ESI-MS and cyclic voltammetry. X-ray crystallography showed the O2N2 donor set to define an octahedral geometry in each case. The complexes (1-7) were tested for their in vitro antiproliferative activity against HT-29 and HeLa cancer cell line. IC50 values of the complexes in HT-29 follow the order 6 < 7 < < 1 < 2 < 5 < < 3 < 4 while the order was 6 < 7 < 5 < 1 < < 3 < 4 < 2 in HeLa cells. Some of the complexes proved to be as active as the clinical referred drugs, and the greater potency of 6 and 7 (IC50 values of 6 are 2.62 and 10.74 mu M and that of 7 is 11.79 and 30.48 mu M in HT-29 and HeLa cells, respectively) may be dependent on the substituents in the salan ligand environment coordinated to the metal.
dc.description.sponsorshipDBT, Govt. of IndiaDepartment of Biotechnology (DBT) India [6241 P112/RGCB/PMD/DBT/RPDA/2015]; Council of Scientific and Industrial Research, New DelhiCouncil of Scientific & Industrial Research (CSIR) - India [01(2735)/13/EMR-II]; The authors thank the reviewers for their comments and suggestions, which were helpful in preparing the revised version of the manuscript. RD thanks DBT, Govt. of India [Grant No. 6241 P112/RGCB/PMD/DBT/RPDA/2015] and Council of Scientific and Industrial Research, New Delhi, [Grant No. 01(2735)/13/EMR-II] for funding this research.
dc.language.isoen
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofJOURNAL OF INORGANIC BIOCHEMISTRY
dc.subjectANTICANCER DRUGS
dc.subjectANTITUMOR-ACTIVITY
dc.subjectBiochemistry & Molecular Biology
dc.subjectCELL-LINES
dc.subjectChemistry
dc.subjectChemistry, Inorganic & Nuclear
dc.subjectCytotoxicity
dc.subjectDNA-BINDING
dc.subjectIN-VITRO
dc.subjectLUNG-CANCER
dc.subjectMETAL-COMPLEXES
dc.subjectOxidomolybdenum(VI)
dc.subjectPLATINUM
dc.subjectRedox
dc.subjectSatan
dc.subjectTHIOSEMICARBAZONATO MOLYBDENUM(VI) COMPLEXES
dc.subjectVANADIUM(V) COMPLEXES
dc.subjectX-ray structure
dc.titleSynthesis, structure and cytotoxicity of a series of Dioxidomolybdenum(VI) complexes featuring Salan ligands
dc.typejournal article
dc.identifier.doi10.1016/j.jinorgbio.2017.04.015
dc.identifier.isiISI:000404000300013
dc.description.volume172
dc.description.startpage110
dc.description.endpage121
dc.contributor.orcid0000-0001-9452-7791
dc.contributor.orcid0000-0003-3634-8765
dc.contributor.researcheridN-5995-2017
dc.identifier.eissn18733344
dc.publisher.place360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
dcterms.isPartOf.abbreviationJ. Inorg. Biochem.
crisitem.author.deptInstitut für Chemie neuer Materialien-
crisitem.author.deptidinstitute11-
crisitem.author.parentorgFB 05 - Biologie/Chemie-
crisitem.author.grandparentorgUniversität Osnabrück-
crisitem.author.netidReHa636-
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