Age-Dependent Enterocyte Invasion and Microcolony Formation by Salmonella
DC Element | Wert | Sprache |
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dc.contributor.author | Zhang, Kaiyi | |
dc.contributor.author | Dupont, Aline | |
dc.contributor.author | Torow, Natalia | |
dc.contributor.author | Gohde, Fredrik | |
dc.contributor.author | Leschner, Sara | |
dc.contributor.author | Lienenklaus, Stefan | |
dc.contributor.author | Weiss, Siegfried | |
dc.contributor.author | Brinkmann, Melanie M. | |
dc.contributor.author | Kuehnel, Mark | |
dc.contributor.author | Hensel, Michael | |
dc.contributor.author | Fulde, Marcus | |
dc.contributor.author | Hornef, Mathias W. | |
dc.date.accessioned | 2021-12-23T16:18:03Z | - |
dc.date.available | 2021-12-23T16:18:03Z | - |
dc.date.issued | 2014 | |
dc.identifier.issn | 15537366 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/12518 | - |
dc.description.abstract | The coordinated action of a variety of virulence factors allows Salmonella enterica to invade epithelial cells and penetrate the mucosal barrier. The influence of the age-dependent maturation of the mucosal barrier for microbial pathogenesis has not been investigated. Here, we analyzed Salmonella infection of neonate mice after oral administration. In contrast to the situation in adult animals, we observed spontaneous colonization, massive invasion of enteroabsorptive cells, intraepithelial proliferation and the formation of large intraepithelial microcolonies. Mucosal translocation was dependent on enterocyte invasion in neonates in the absence of microfold (M) cells. It further resulted in potent innate immune stimulation in the absence of pronounced neutrophil-dominated pathology. Our results identify factors of age-dependent host susceptibility and provide important insight in the early steps of Salmonella infection in vivo. We also present a new small animal model amenable to genetic manipulation of the host for the analysis of the Salmonella enterocyte interaction in vivo. | |
dc.description.sponsorship | German Research FoundationGerman Research Foundation (DFG) [1656, 1580]; Lower Saxony Ministry of Science and Culture; Collaborative Research Center [SFB900]; Hannover Biomedical Research School (HBRS); Center for Infection Biology; Lower Saxony-Israel Found; international research training group [IRTG1273]; Collaborative Research Center of the German Research Foundation [P4, SFB944]; [Ho2236/8-1]; MWH and MF were supported by the individual grant Ho2236/8-1 and the Priority Programs 1656 and 1580 supported by the German Research Foundation (www.dfg.de) and the Niedersachsen-Research Network on Neuroinfectiology (N-RENNT) supported by the Lower Saxony Ministry of Science and Culture (www.mwk.niedersachsen.de). MWH and MMB received support from the Collaborative Research Center SFB900 (A4 and B3, respectively). KZ and AD were supported by Hannover Biomedical Research School (HBRS) and the Center for Infection Biology (ZIB) and the Lower Saxony-Israel Found, NT by the international research training group (IRTG1273). MH was supported by grant P4 within Collaborative Research Center SFB944 of the German Research Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | |
dc.language.iso | en | |
dc.publisher | PUBLIC LIBRARY SCIENCE | |
dc.relation.ispartof | PLOS PATHOGENS | |
dc.subject | AUTOPHAGY | |
dc.subject | BACTERIAL-MENINGITIS | |
dc.subject | DENDRITIC CELLS | |
dc.subject | EFFECTOR PROTEINS SIPA | |
dc.subject | ENTERICA SEROTYPE TYPHIMURIUM | |
dc.subject | INFECTION | |
dc.subject | INTESTINAL EPITHELIUM | |
dc.subject | M-CELLS | |
dc.subject | Microbiology | |
dc.subject | Parasitology | |
dc.subject | PATHOGENICITY ISLANDS | |
dc.subject | SEROVAR TYPHIMURIUM | |
dc.subject | Virology | |
dc.title | Age-Dependent Enterocyte Invasion and Microcolony Formation by Salmonella | |
dc.type | journal article | |
dc.identifier.doi | 10.1371/journal.ppat.1004385 | |
dc.identifier.isi | ISI:000343014600042 | |
dc.description.volume | 10 | |
dc.description.issue | 9 | |
dc.contributor.orcid | 0000-0003-4790-3445 | |
dc.identifier.eissn | 15537374 | |
dc.publisher.place | 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA | |
dcterms.isPartOf.abbreviation | PLoS Pathog. | |
dcterms.oaStatus | Green Published, gold, Green Submitted | |
crisitem.author.dept | FB 05 - Biologie/Chemie | - |
crisitem.author.deptid | fb05 | - |
crisitem.author.orcid | 0000-0001-6604-6253 | - |
crisitem.author.parentorg | Universität Osnabrück | - |
crisitem.author.netid | HeMi480 | - |
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geprüft am 10.06.2024