Synthesis of new 2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-yloxyl radicals and 2-substituted-2,5,5-trimethylpyrrolidin-1-yloxyl radicals based alpha-amino acids
| Autor(en): | Balog, MR Kalai, TK Jeko, J Steinhoff, HJ Engelhard, M Hideg, K |
Stichwörter: | amino acids; azides; Chemistry; Chemistry, Organic; CROSS-LINKING; DERIVATIVES; free-radicals; NITROXIDE; O'Donnell synthesis; PROBES; protecting groups; PROTEINS; SPIN-LABEL REAGENTS | Erscheinungsdatum: | 2004 | Herausgeber: | GEORG THIEME VERLAG KG | Journal: | SYNLETT | Ausgabe: | 14 | Startseite: | 2591 | Seitenende: | 2593 | Zusammenfassung: | Unnatural paramagnetic alpha-amino acids with 2,2,5,5-tetramethyl-2.5-dihydro-1H-pyrrol-1-yloxyl-3-yl radical or 2,5,5-trimethylpyrrolidin-1-yloxyl-2-yl radical side-chains, including a lysine mimic azido precursor and their derivatives, are described. The new set of paramagnetic amino acids presented in this work with different (polar. nonpolar. aliphatic, aromatic, etc.) side-chains offers a useful tool for the ESR study of the protein structure and function after incorporation. fulfilling diverse structural requirements. |
ISSN: | 09365214 | DOI: | 10.1055/s-2004-834806 |
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geprüft am 02.05.2024
