DC Field | Value | Language |
dc.contributor.author | Crull, Katja | |
dc.contributor.author | Rohde, Manfred | |
dc.contributor.author | Westphal, Kathrin | |
dc.contributor.author | Loessner, Holger | |
dc.contributor.author | Wolf, Kathrin | |
dc.contributor.author | Felipe-Lopez, Alfonso | |
dc.contributor.author | Hensel, Michael | |
dc.contributor.author | Weiss, Siegfried | |
dc.date.accessioned | 2021-12-23T16:18:25Z | - |
dc.date.available | 2021-12-23T16:18:25Z | - |
dc.date.issued | 2011 | |
dc.identifier.issn | 14625814 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/12677 | - |
dc.description.abstract | Systemic administration of Salmonella enterica serovar Typhimurium to tumour bearing mice results in preferential colonization of the tumours and retardation of tumour growth. Although the bacteria are able to invade the tumour cells in vitro, in tumours they were never detected intracellularly. Ultrastructural analysis of Salmonella-colonized tumours revealed that the bacteria had formed biofilms. Interestingly, depletion of neutrophilic granulocytes drastically reduced biofilm formation. Obviously, bacteria form biofilms in response to the immune reactions of the host. Importantly, we tested Salmonella mutants that were no longer able to form biofilms by deleting central regulators of biofilm formation. Such bacteria could be observed intracellularly in immune cells of the host or in tumour cells. Thus, tumour colonizing S. typhimurium might form biofilms as protection against phagocytosis. Since other bacteria are behaving similarly, solid murine tumours might represent a unique model to study biofilm formation in vivo. | |
dc.description.sponsorship | Deutsche KrebshilfeDeutsche Krebshilfe; Ministry of Education and Research (BMBF)Federal Ministry of Education & Research (BMBF); German Research Council (DFG)German Research Foundation (DFG); The authors wish to thank Susanne zur Lage, Regina Lesch and Ina Schleicher for expert technical assistance. This work was supported in part by the Deutsche Krebshilfe, the Ministry of Education and Research (BMBF) and the German Research Council (DFG). | |
dc.language.iso | en | |
dc.publisher | WILEY | |
dc.relation.ispartof | CELLULAR MICROBIOLOGY | |
dc.subject | BACTERIA | |
dc.subject | Cell Biology | |
dc.subject | CELLULOSE | |
dc.subject | CURLI | |
dc.subject | ESCHERICHIA-COLI | |
dc.subject | GENE-EXPRESSION | |
dc.subject | Microbiology | |
dc.subject | MULTICELLULAR BEHAVIOR | |
dc.subject | SPP. | |
dc.subject | THIN AGGREGATIVE FIMBRIAE | |
dc.title | Biofilm formation by Salmonella enterica serovar Typhimurium colonizing solid tumours | |
dc.type | journal article | |
dc.identifier.doi | 10.1111/j.1462-5822.2011.01612.x | |
dc.identifier.isi | ISI:000292845700010 | |
dc.description.volume | 13 | |
dc.description.issue | 8 | |
dc.description.startpage | 1223 | |
dc.description.endpage | 1233 | |
dc.identifier.eissn | 14625822 | |
dc.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | |
dcterms.isPartOf.abbreviation | Cell Microbiol. | |
dcterms.oaStatus | Green Published | |
crisitem.author.dept | FB 05 - Biologie/Chemie | - |
crisitem.author.deptid | fb05 | - |
crisitem.author.orcid | 0000-0001-6604-6253 | - |
crisitem.author.parentorg | Universität Osnabrück | - |
crisitem.author.netid | HeMi480 | - |