Ubiquinone reduction in the photosynthetic reaction centre of Rhodobacter sphaeroides: interplay between electron transfer, proton binding and flips of the quinone ring
Autor(en): | Mulkidjanian, AY Kozlova, MA Cherepanov, DA |
Stichwörter: | BACTERIAL REACTION CENTERS; Biochemistry & Molecular Biology; conformational gating; INDUCED STRUCTURAL-CHANGES; MEMBRANE/WATER INTERFACE; MOLECULAR-DYNAMICS; MUTANT REACTION CENTERS; protein dynamics; proton transfer; PURPLE BACTERIA; Rhodobacter sphaeroides; RHODOPSEUDOMONAS-SPHAEROIDES; SECONDARY QUINONE; semiquinone; TEMPERATURE-DEPENDENCE; ubiquinol; WILD-TYPE | Erscheinungsdatum: | 2005 | Herausgeber: | PORTLAND PRESS LTD | Enthalten in: | BIOCHEMICAL SOCIETY TRANSACTIONS | Band: | 33 | Ausgabe: | 4 | Startseite: | 845 | Seitenende: | 850 | Zusammenfassung: | This review is focused on reactions that gate (control) the electron transfer between the primary quinone Q(A) and secondary quinone Q(B) in the photosynthetic reaction centre of Rhodobacter sphaeroides. The results on electron and proton transfer are discussed in relation to structural information and to the steered molecular dynamics simulations of the Q(B) ring flip in its binding pocket. Depending on the initial position of Q(B) in the pocket and on certain conditions, the rate of electron transfer is suggested to be limited either by the quirpone ring flip or by the charge-compensating proton equilibration between the surface and the buried Q(B) site. |
Beschreibung: | Conference on Mechanisms of Bioenergetic Membrane Proteins - Structures and Beyond, Wilhelm-Kempf Haus, Wiesbaden, GERMANY, MAR 20-24, 2005 |
ISSN: | 03005127 | DOI: | 10.1042/BST0330845 |
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