A closer look at the apparent correlation of structural and functional connectivity in excitable neural networks
DC Element | Wert | Sprache |
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dc.contributor.author | Messe, Arnaud | |
dc.contributor.author | Huett, Marc-Thorsten | |
dc.contributor.author | Koenig, Peter | |
dc.contributor.author | Hilgetag, Claus C. | |
dc.date.accessioned | 2021-12-23T16:20:22Z | - |
dc.date.available | 2021-12-23T16:20:22Z | - |
dc.date.issued | 2015 | |
dc.identifier.issn | 20452322 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/13425 | - |
dc.description.abstract | The relationship between the structural connectivity (SC) and functional connectivity (FC) of neural systems is a central focus in brain network science. It is an open question, however, how strongly the SC-FC relationship depends on specific topological features of brain networks or the models used for describing excitable dynamics. Using a basic model of discrete excitable units that follow a susceptible -excited refractory dynamic cycle (SER model), we here analyze how functional connectivity is shaped by the topological features of a neural network, in particular its modularity. We compared the results obtained by the SER model with corresponding simulations by another well established dynamic mechanism, the Fitzhugh-Nagumo model, in order to explore general features of the SC-FC relationship. We showed that apparent discrepancies between the results produced by the two models can be resolved by adjusting the time window of integration of co-activations from which the FC is derived, providing a clearer distinction between co-activations and sequential activations. Thus, network modularity appears as an important factor shaping the FC-SC relationship across different dynamic models. | |
dc.description.sponsorship | Deutsche Forschungsgemeinschaft (DFG)German Research Foundation (DFG) [SFB 936/Z1, HU 937/7, SFB 936/B6, ERC-2010-AdG, 269716, HI 1286/5-1, 936/A1]; AM is supported by Deutsche Forschungsgemeinschaft (DFG) grant SFB 936/Z1. MTH acknowledges support from DFG grant HU 937/7. PK is supported by DFG grants SFB 936/B6 and ERC-2010-AdG #269716. CCH is supported by DFG grants HI 1286/5-1 and SFB 936/A1. | |
dc.language.iso | en | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.relation.ispartof | SCIENTIFIC REPORTS | |
dc.subject | Multidisciplinary Sciences | |
dc.subject | RESTING-STATE | |
dc.subject | Science & Technology - Other Topics | |
dc.subject | TOPOLOGY | |
dc.title | A closer look at the apparent correlation of structural and functional connectivity in excitable neural networks | |
dc.type | journal article | |
dc.identifier.doi | 10.1038/srep07870 | |
dc.identifier.isi | ISI:000347978600009 | |
dc.description.volume | 5 | |
dc.contributor.orcid | 0000-0003-3654-5267 | |
dc.contributor.orcid | 0000-0003-2129-8910 | |
dc.contributor.orcid | 0000-0001-9081-3088 | |
dc.contributor.researcherid | ABB-2380-2020 | |
dc.contributor.researcherid | AAH-1760-2020 | |
dc.contributor.researcherid | I-1738-2019 | |
dc.publisher.place | MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND | |
dcterms.isPartOf.abbreviation | Sci Rep | |
dcterms.oaStatus | Green Published, gold | |
crisitem.author.dept | Universität Osnabrück | - |
crisitem.author.dept | Institut für Kognitionswissenschaft | - |
crisitem.author.dept | FB 05 - Biologie/Chemie | - |
crisitem.author.deptid | institute28 | - |
crisitem.author.deptid | fb05 | - |
crisitem.author.orcid | 0000-0003-3654-5267 | - |
crisitem.author.parentorg | FB 08 - Humanwissenschaften | - |
crisitem.author.parentorg | Universität Osnabrück | - |
crisitem.author.grandparentorg | Universität Osnabrück | - |
crisitem.author.netid | MeAr001 | - |
crisitem.author.netid | KoPe298 | - |
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geprüft am 19.05.2024