Glutamate forward and reverse transport: From molecular mechanism to transporter-mediated release after ischemia
DC Element | Wert | Sprache |
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dc.contributor.author | Grewer, Christof | |
dc.contributor.author | Gameiro, Armanda | |
dc.contributor.author | Zhang, Zhou | |
dc.contributor.author | Tao, Zhen | |
dc.contributor.author | Braams, Simona | |
dc.contributor.author | Rauen, Thomas | |
dc.date.accessioned | 2021-12-23T16:20:58Z | - |
dc.date.available | 2021-12-23T16:20:58Z | - |
dc.date.issued | 2008 | |
dc.identifier.issn | 15216543 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/13672 | - |
dc.description.abstract | Glutamate transporters remove the excitatory neurotransmitter glutamate from the extracellular space after neurotransmission is complete, by taking glutamate up into neurons and glia cells. As thermodynamic machines, these transporters can also run in reverse, releasing glutamate into the extracellular space. Because glutamate is excitotoxic, this transporter-mediated release is detrimental to the health of neurons and axons, and it, thus, contributes to the brain damage that typically follows a stroke. This review highlights current ideas about the molecular mechanisms underlying glutamate uptake and glutamate reverse transport. It also discusses the implications of transporter-mediated glutamate release for cellular function under physiological and patho-physiological conditions. (C) 2008 IUBMB. | |
dc.description.sponsorship | National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01-NS0493]; Deutsche ForschungsgeineinschaftGerman Research Foundation (DFG) [1393/2-2,3, 753/1-1,2]; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R56NS049335] Funding Source: NIH RePORTER; This work was supported by the National Institutes of Health Grant R01-NS0493 to CG and by the Deutsche Forschungsgeineinschaft Grants GR 1393/2-2,3 to CG and RA 753/1-1,2 to TR. | |
dc.language.iso | en | |
dc.publisher | WILEY | |
dc.relation.ispartof | IUBMB LIFE | |
dc.subject | AMINO-ACID TRANSPORTER | |
dc.subject | ANION CONDUCTANCE | |
dc.subject | ASPARTATE | |
dc.subject | Biochemistry & Molecular Biology | |
dc.subject | Cell Biology | |
dc.subject | CL-COTRANSPORT FUNCTION | |
dc.subject | electrophysiology | |
dc.subject | GLT-1 | |
dc.subject | glutamate release | |
dc.subject | glutamate transporter | |
dc.subject | ION-BINDING | |
dc.subject | KINETICS | |
dc.subject | NA+ | |
dc.subject | reverse transports | |
dc.subject | SUBSTRATE INTERACTIONS | |
dc.subject | TRANSLOCATION | |
dc.subject | transport mechanism | |
dc.title | Glutamate forward and reverse transport: From molecular mechanism to transporter-mediated release after ischemia | |
dc.type | review | |
dc.identifier.doi | 10.1002/iub.98 | |
dc.identifier.isi | ISI:000258893900007 | |
dc.description.volume | 60 | |
dc.description.issue | 9 | |
dc.description.startpage | 609 | |
dc.description.endpage | 619 | |
dc.contributor.orcid | 0000-0001-9699-182X | |
dc.contributor.researcherid | A-9082-2012 | |
dc.identifier.eissn | 15216551 | |
dc.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | |
dcterms.isPartOf.abbreviation | IUBMB Life | |
dcterms.oaStatus | Green Accepted |
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