STN-DBS Reduces Saccadic Hypometria but Not Visuospatial Bias in Parkinson's Disease Patients

DC FieldValueLanguage
dc.contributor.authorFischer, Petra
dc.contributor.authorOssandon, Jose P.
dc.contributor.authorKeyser, Johannes
dc.contributor.authorGulberti, Alessandro
dc.contributor.authorWilming, Niklas
dc.contributor.authorHamel, Wolfgang
dc.contributor.authorKoeppen, Johannes
dc.contributor.authorBuhmann, Carsten
dc.contributor.authorWestphal, Manfred
dc.contributor.authorGerloff, Christian
dc.contributor.authorMoll, Christian K. E.
dc.contributor.authorEngel, Andreas K.
dc.contributor.authorKoenig, Peter
dc.date.accessioned2021-12-23T16:20:59Z-
dc.date.available2021-12-23T16:20:59Z-
dc.date.issued2016
dc.identifier.issn16625153
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/13680-
dc.description.abstractIn contrast to its well-established role in alleviating skeleto-motor symptoms in Parkinson's disease, little is known about the impact of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on oculomotor control and attention. Eye-tracking data of 17 patients with left-hemibody symptom onset was compared with 17 age-matched control subjects. Free-viewing of natural images was assessed without stimulation as baseline and during bilateral DBS. To examine the involvement of ventral STN territories in oculomotion and spatial attention, we employed unilateral stimulation via the left and right ventralmost contacts respectively. When DBS was off, patients showed shorter saccades and a rightward viewing bias compared with controls. Bilateral stimulation in therapeutic settings improved saccadic hypometria but not the visuospatial bias. At a group level, unilateral ventral stimulation yielded no consistent effects. However, the evaluation of electrode position within normalized MNI coordinate space revealed that the extent of early exploration bias correlated with the precise stimulation site within the left subthalamic area. These results suggest that oculomotor impairments ``but not higher-level exploration patterns'' are effectively ameliorable by DBS in therapeutic settings. Our findings highlight the relevance of the STN topography in selecting contacts for chronic stimulation especially upon appearance of visuospatial attention deficits.
dc.description.sponsorshipEUEuropean Commission [FP7-ICT-270212, ERC-2010-AdG-269716]; DFGGerman Research Foundation (DFG)European Commission [SFB936/A3/B6/C1/C8]; This study was supported by funding from the EU (FP7-ICT-270212, ERC-2010-AdG-269716, AKE, PK) and the DFG (SFB936/A3/B6/C1/C8, AKE, PK, CG, AG, CKEM).
dc.language.isoen
dc.publisherFRONTIERS MEDIA SA
dc.relation.ispartofFRONTIERS IN BEHAVIORAL NEUROSCIENCE
dc.subjectBASAL GANGLIA
dc.subjectBehavioral Sciences
dc.subjectdeep brain stimulation
dc.subjectDEEP BRAIN-STIMULATION
dc.subjectEYE-MOVEMENTS
dc.subjectHEMIPARKINSONS-DISEASE
dc.subjectLINE BISECTION
dc.subjectMONKEY
dc.subjectneglect
dc.subjectNeurosciences
dc.subjectNeurosciences & Neurology
dc.subjectoculomotor control
dc.subjectOCULOMOTOR FUNCTIONS
dc.subjectRESPONSES
dc.subjectsubthalamic nucleus
dc.subjectSUBTHALAMIC NUCLEUS STIMULATION
dc.subjectunilateral stimulation
dc.subjectviewing bias
dc.subjectvisual attention
dc.subjectZONA INCERTA
dc.titleSTN-DBS Reduces Saccadic Hypometria but Not Visuospatial Bias in Parkinson's Disease Patients
dc.typejournal article
dc.identifier.doi10.3389/fnbeh.2016.00085
dc.identifier.isiISI:000375538900001
dc.description.volume10
dc.contributor.orcid0000-0003-4899-8466
dc.contributor.orcid0000-0003-4899-8466
dc.contributor.orcid0000-0003-3654-5267
dc.contributor.orcid0000-0001-8343-4362
dc.contributor.orcid0000-0002-6484-8882
dc.contributor.orcid0000-0003-0538-5109
dc.contributor.orcid0000-0003-0663-9828
dc.contributor.orcid0000-0001-5585-8977
dc.contributor.researcheridAAH-6384-2019
dc.contributor.researcheridC-7781-2012
dc.contributor.researcheridABB-2380-2020
dc.publisher.placePO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND
dcterms.isPartOf.abbreviationFront. Behav. Neurosci.
dcterms.oaStatusGreen Published, gold
crisitem.author.deptUniversität Osnabrück-
crisitem.author.deptUniversität Osnabrück-
crisitem.author.deptInstitut für Kognitionswissenschaft-
crisitem.author.deptUniversität Osnabrück-
crisitem.author.deptUniversität Osnabrück-
crisitem.author.deptUniversität Osnabrück-
crisitem.author.deptUniversität Osnabrück-
crisitem.author.deptUniversität Osnabrück-
crisitem.author.deptInstitut für Kognitionswissenschaft-
crisitem.author.deptFB 05 - Biologie/Chemie-
crisitem.author.deptidinstitute28-
crisitem.author.deptidinstitute28-
crisitem.author.deptidfb05-
crisitem.author.orcid0000-0001-5585-8977-
crisitem.author.orcid0000-0001-8343-4362-
crisitem.author.orcid0000-0003-0663-9828-
crisitem.author.orcid0000-0003-3654-5267-
crisitem.author.parentorgFB 08 - Humanwissenschaften-
crisitem.author.parentorgFB 08 - Humanwissenschaften-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.grandparentorgUniversität Osnabrück-
crisitem.author.grandparentorgUniversität Osnabrück-
crisitem.author.netidFiPe001-
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crisitem.author.netidKoPe298-
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