Structure and regulation of the dnaA promoter region in three Streptomyces species

DC FieldValueLanguage
dc.contributor.authorJakimowicz, D
dc.contributor.authorMajka, J
dc.contributor.authorLis, B
dc.contributor.authorKonopa, G
dc.contributor.authorWegrzyn, G
dc.contributor.authorMesser, W
dc.contributor.authorSchrempf, H
dc.contributor.authorZakrzewska-Czerwinska, J
dc.date.accessioned2021-12-23T16:21:04Z-
dc.date.available2021-12-23T16:21:04Z-
dc.date.issued2000
dc.identifier.issn00268925
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/13717-
dc.description.abstractThe regulatory region of the Streptomyces dnaA gene comprises a single promoter and two DnaA boxes that are located upstream of the promoter. Comparative analysis of the dnaA promoter region from S. chrysomallus, S. lividans and S. reticuli revealed that the location, spacing and orientation of the DnaA boxes are conserved. In vitro studies demonstrated that efficient binding of the Streptomyces DnaA protein to DNA requires the presence of two DnaA boxes. In vivo analysis of dnaA promoter mutants deleted for one or both DnaA boxes indicated that the dnaA gene is autoregulated. However, the degree of derepression observed is relatively modest.
dc.language.isoen
dc.publisherSPRINGER
dc.relation.ispartofMOLECULAR AND GENERAL GENETICS
dc.subjectAUTO-REGULATION
dc.subjectautoregulation
dc.subjectBINDING
dc.subjectBiochemistry & Molecular Biology
dc.subjectCHROMOSOME
dc.subjectDnaA box
dc.subjectDnaA protein
dc.subjectELEMENTS
dc.subjectESCHERICHIA-COLI
dc.subjectGENE
dc.subjectGenetics & Heredity
dc.subjectINITIATOR PROTEIN DNAA
dc.subjectpromoter
dc.subjectREPLICATION
dc.subjectSEQUENCE
dc.subjectTRANSCRIPTIONAL ACTIVATION
dc.titleStructure and regulation of the dnaA promoter region in three Streptomyces species
dc.typejournal article
dc.identifier.doi10.1007/PL00008652
dc.identifier.isiISI:000084930100020
dc.description.volume262
dc.description.issue6
dc.description.startpage1093
dc.description.endpage1102
dc.contributor.orcid0000-0003-4042-7466
dc.contributor.orcid0000-0002-7857-064X
dc.contributor.researcheridAAK-1908-2021
dc.contributor.researcheridAAL-1179-2020
dc.contributor.researcheridABD-6699-2020
dc.publisher.placeONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
dcterms.isPartOf.abbreviationMol. Gen. Genet.
crisitem.author.deptFB 05 - Biologie/Chemie-
crisitem.author.deptidfb05-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.netidScHi752-
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