A 2'->5'-adenylate trimer with a positively charged 2'(3')-terminal 8-(4-aminobutyl)aminoadenosine residue: Synthesis, conformation and RNase L binding

DC FieldValueLanguage
dc.contributor.authorMikhailopulo, IA
dc.contributor.authorKalinichenko, EN
dc.contributor.authorPodkopaeva, TL
dc.contributor.authorKelve, M
dc.contributor.authorSaarma, M
dc.contributor.authorLidaks, MY
dc.contributor.authorRosemeyer, H
dc.contributor.authorSeela, F
dc.date.accessioned2021-12-23T16:21:18Z-
dc.date.available2021-12-23T16:21:18Z-
dc.date.issued1997
dc.identifier.issn15257770
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/13810-
dc.description.abstractAn analogue of the 2-5A core trimer containing an 8-(4-aminobutyl)-aminoadenosine (1, A*) residue at the 2'(3')-terminus [2; (2',5')A(2)A*] was synthesized. The conformation of (2',5')A(2)A* was studied by H-1, C-13-NMR, and CD spectroscopy. The (2',5')A(2)A* exhibits very low binding ability to the RNase L of mouse L cells, but slightly enhanced resistance to digestion by SVPD compared to the parent trimer.
dc.language.isoen
dc.publisherTAYLOR & FRANCIS INC
dc.relation.ispartofNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
dc.subject2-5A
dc.subjectACID
dc.subjectANALOGS
dc.subjectANTI CONFORMATION
dc.subjectBiochemistry & Molecular Biology
dc.subjectBOND
dc.subjectFRAGMENTS
dc.subjectNMR
dc.subjectNUCLEAR MAGNETIC-RESONANCE
dc.subjectNUCLEOTIDES
dc.subjectPURINE NUCLEOSIDES
dc.titleA 2'->5'-adenylate trimer with a positively charged 2'(3')-terminal 8-(4-aminobutyl)aminoadenosine residue: Synthesis, conformation and RNase L binding
dc.typejournal article
dc.identifier.doi10.1080/07328319708002539
dc.identifier.isiISI:A1997YK89500005
dc.description.volume16
dc.description.issue10-11
dc.description.startpage1855
dc.description.endpage1873
dc.identifier.eissn15322335
dc.publisher.place530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
dcterms.isPartOf.abbreviationNucleosides Nucleotides Nucleic Acids
crisitem.author.deptInstitut für Chemie neuer Materialien-
crisitem.author.deptidinstitute11-
crisitem.author.parentorgFB 05 - Biologie/Chemie-
crisitem.author.grandparentorgUniversität Osnabrück-
crisitem.author.netidRoHe783-
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