Alpha-Gal-associated delayed redmeat anaphylaxis as an occupational disease

Abstract

In a30-year-old chef with recurrent delayed angioedema history as well as the experimental detection of IgE antibodies against galactose-alpha-(1,3)-galactose (alpha-Gal) pointed to alpha-Gal as the causative agent. The diagnosis, therefore, was delayed anaphylaxis due to alpha-Gal. Because of the potential relationship to his profession, we submitted adermatologist's report BK 5101 to the liability and insurance association, whereupon his contract of employment was terminated without notice. As aconsequence, we reported an occupational disease. This case demonstrates an underdiagnosed, potentially life-threatening allergy to the disaccharide alpha-Gal in red meat as an occupational disease.