pH-Regulated Mechanisms Account for Pigment-Type Differences in Epidermal Barrier Function

Autor(en): Gunathilake, Roshan
Schurer, Nanna Y.
Shoo, Brenda A.
Celli, Anna
Hachem, Jean-Pierre
Crumrine, Debra
Sirimanna, Ganga
Feingold, Kenneth R.
Mauro, Theodora M.
Elias, Peter M.
Stichwörter: ACIDIFICATION; CATHEPSIN-D; DEGRADATION; Dermatology; HOMEOSTASIS; MELANIN; MELANOSOMES; NEUTRAL PH; SERINE PROTEASES; SKIN TYPE
Erscheinungsdatum: 2009
Herausgeber: ELSEVIER SCIENCE INC
Enthalten in: JOURNAL OF INVESTIGATIVE DERMATOLOGY
Band: 129
Ausgabe: 7
Startseite: 1719
Seitenende: 1729
Zusammenfassung: 
To determine whether pigment type determines differences in epidermal function, we studied stratum corneum (SC) pH, permeability barrier homeostasis, and SC integrity in three geographically disparate populations with pigment type I-II versus IV-V skin (Fitzpatrick I-VI scale). Type IV-V subjects showed: (i) lower surface pH (approximate to 0.5 U); (ii) enhanced SC integrity (transepidermal water loss change with sequential tape strippings); and (iii) more rapid barrier recovery than type I-II subjects. Enhanced barrier function could be ascribed to increased epidermal lipid content, increased lamellar body production, and reduced acidity, leading to enhanced lipid processing. Compromised SC integrity in type I-II subjects could be ascribed to increased serine protease activity, resulting in accelerated desmoglein-1 (DSG-1)/corneodesmosome degradation. In contrast, DSG-1-positive CDs persisted in type IV-V subjects, but due to enhanced cathepsin-D activity, SC thickness did not increase. Adjustment of pH of type I-II SC to type IV-V levels improved epidermal function. Finally, dendrites from type IV-V melanocytes were more acidic than those from type I-II subjects, and they transfer more melanosomes to the SC, suggesting that melanosome secretion could contribute to the more acidic pH of type IV-V skin. These studies show marked pigment-type differences in epidermal structure and function that are pH driven.
ISSN: 0022202X
DOI: 10.1038/jid.2008.442

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