pH-Regulated Mechanisms Account for Pigment-Type Differences in Epidermal Barrier Function

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dc.contributor.authorGunathilake, Roshan
dc.contributor.authorSchurer, Nanna Y.
dc.contributor.authorShoo, Brenda A.
dc.contributor.authorCelli, Anna
dc.contributor.authorHachem, Jean-Pierre
dc.contributor.authorCrumrine, Debra
dc.contributor.authorSirimanna, Ganga
dc.contributor.authorFeingold, Kenneth R.
dc.contributor.authorMauro, Theodora M.
dc.contributor.authorElias, Peter M.
dc.date.accessioned2021-12-23T16:21:34Z-
dc.date.available2021-12-23T16:21:34Z-
dc.date.issued2009
dc.identifier.issn0022202X
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/13929-
dc.description.abstractTo determine whether pigment type determines differences in epidermal function, we studied stratum corneum (SC) pH, permeability barrier homeostasis, and SC integrity in three geographically disparate populations with pigment type I-II versus IV-V skin (Fitzpatrick I-VI scale). Type IV-V subjects showed: (i) lower surface pH (approximate to 0.5 U); (ii) enhanced SC integrity (transepidermal water loss change with sequential tape strippings); and (iii) more rapid barrier recovery than type I-II subjects. Enhanced barrier function could be ascribed to increased epidermal lipid content, increased lamellar body production, and reduced acidity, leading to enhanced lipid processing. Compromised SC integrity in type I-II subjects could be ascribed to increased serine protease activity, resulting in accelerated desmoglein-1 (DSG-1)/corneodesmosome degradation. In contrast, DSG-1-positive CDs persisted in type IV-V subjects, but due to enhanced cathepsin-D activity, SC thickness did not increase. Adjustment of pH of type I-II SC to type IV-V levels improved epidermal function. Finally, dendrites from type IV-V melanocytes were more acidic than those from type I-II subjects, and they transfer more melanosomes to the SC, suggesting that melanosome secretion could contribute to the more acidic pH of type IV-V skin. These studies show marked pigment-type differences in epidermal structure and function that are pH driven.
dc.description.sponsorshipNIAMS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) [R01 AR019098-32A2, R01 AR019098] Funding Source: Medline; NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) [R01AR019098] Funding Source: NIH RePORTER
dc.language.isoen
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofJOURNAL OF INVESTIGATIVE DERMATOLOGY
dc.subjectACIDIFICATION
dc.subjectCATHEPSIN-D
dc.subjectDEGRADATION
dc.subjectDermatology
dc.subjectHOMEOSTASIS
dc.subjectMELANIN
dc.subjectMELANOSOMES
dc.subjectNEUTRAL PH
dc.subjectSERINE PROTEASES
dc.subjectSKIN TYPE
dc.titlepH-Regulated Mechanisms Account for Pigment-Type Differences in Epidermal Barrier Function
dc.typejournal article
dc.identifier.doi10.1038/jid.2008.442
dc.identifier.isiISI:000267270300020
dc.description.volume129
dc.description.issue7
dc.description.startpage1719
dc.description.endpage1729
dc.contributor.orcid0000-0002-3241-0974
dc.identifier.eissn15231747
dc.publisher.placeSTE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
dcterms.isPartOf.abbreviationJ. Invest. Dermatol.
dcterms.oaStatusGreen Accepted, Bronze
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