DC Element | Wert | Sprache |
dc.contributor.author | Bingold, Tobias M. | |
dc.contributor.author | Just, Lara | |
dc.contributor.author | Cuca, Colleen | |
dc.contributor.author | Zacharowski, Kai | |
dc.contributor.author | Moench, Christian | |
dc.contributor.author | Muehl, Heiko | |
dc.contributor.author | Wissing, Heimo | |
dc.contributor.author | Pipa, Gordon | |
dc.contributor.author | Rosenberger, Peter | |
dc.contributor.author | Bechstein, Wolf O. | |
dc.contributor.author | Paulus, Patrick | |
dc.contributor.author | Scheller, Bertram | |
dc.date.accessioned | 2021-12-23T16:21:41Z | - |
dc.date.available | 2021-12-23T16:21:41Z | - |
dc.date.issued | 2014 | |
dc.identifier.issn | 14259524 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/13980 | - |
dc.description.abstract | Background: Recent findings support the idea that interleukin (IL)-22 serum levels are related to disease severity in end-stage liver disease. Existing scoring systems - Model for End-Stage Liver Disease (MELD), Survival Outcomes Following Liver Transplantation (SOFT) and Pre-allocation-SOFT (P-SOFT) - are well-established in appraising survival rates with or without liver transplantation. We tested the hypothesis that IL-22 serum levels at transplantation date correlate with survival and potentially have value as a predictive factor for survival. Material/Methods: MELD, SOFT, and P-SOFT scores were calculated to estimate post-transplantation survival. Serum levels of IL-22, IL-6, IL-10, C-reactive protein (CRP), and procalcitonin (PCT) were collected prior to transplantation in 41 patients. Outcomes were assessed at 3 months, 1 year, and 3 years after transplantation. Results: IL-22 significantly correlated with MELD, P-SOFT, and SOFT scores (Rs 0.35, 0.63, 0.56 respectively, p<0.05) and with the discrimination in post-transplantation survival. IL-6 showed a heterogeneous pattern (Rs 0.40, 0.63, 0.57, respectively, p<0.05); CRP and PCT did not correlate. We therefore added IL-22 serum values to existing scoring systems in a generalized linear model (GLM), resulting in a significantly improved outcome prediction in 58% of the cases for both the P-SOFT (p<0.01) and SOFT scores (p<0.001). Conclusions: Further studies are needed to address the concept that IL-22 serum values at the time of transplantation provide valuable information about survival rates following orthotopic liver transplantation. | |
dc.description.sponsorship | Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy; This work was supported by a personal grant to T.M.B. by the Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy | |
dc.language.iso | en | |
dc.publisher | INT SCIENTIFIC INFORMATION, INC | |
dc.relation.ispartof | ANNALS OF TRANSPLANTATION | |
dc.subject | CELLS | |
dc.subject | CIRRHOSIS | |
dc.subject | CYTOKINES | |
dc.subject | DISEASE | |
dc.subject | End Stage Liver Disease | |
dc.subject | HEPATOCELLULAR-CARCINOMA | |
dc.subject | Liver Transplantation | |
dc.subject | MELD | |
dc.subject | MODEL | |
dc.subject | Patient Outcome Assessment | |
dc.subject | SEVERITY | |
dc.subject | Surgery | |
dc.subject | SURVIVAL | |
dc.subject | Transplantation | |
dc.subject | UNITED-STATES | |
dc.title | Preoperative Interleukin-22 Values Add Valuable Information for Outcome Prediction Following Orthotopic Liver Transplantation: A Preliminary Study | |
dc.type | journal article | |
dc.identifier.isi | ISI:000343066500001 | |
dc.description.volume | 19 | |
dc.contributor.orcid | 0000-0002-3267-8145 | |
dc.contributor.researcherid | H-5457-2019 | |
dc.contributor.researcherid | AAM-9204-2021 | |
dc.publisher.place | 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA | |
dcterms.isPartOf.abbreviation | Ann. Transpl. | |
crisitem.author.dept | Institut für Kognitionswissenschaft | - |
crisitem.author.deptid | institute28 | - |
crisitem.author.orcid | 0000-0002-3416-2652 | - |
crisitem.author.parentorg | FB 08 - Humanwissenschaften | - |
crisitem.author.grandparentorg | Universität Osnabrück | - |
crisitem.author.netid | PiGo340 | - |