Stratum corneum profiles of inflammatory mediators in patch test reactions to common contact allergens and sodium lauryl sulfate
Autor(en): | Koppes, S. A. Hadzavdic, S. Ljubojevic Jakasa, I. Franceschi, N. Toncic, R. Jurakic Marinovic, B. Brans, R. Gibbs, S. Frings-Dresen, M. H. W. Rustemeyer, T. Kezic, S. |
Stichwörter: | ATOPIC-DERMATITIS; BARRIER; CELLS; Dermatology; EPIDEMIOLOGY; INTERLEUKIN-1-ALPHA | Erscheinungsdatum: | 2017 | Herausgeber: | WILEY | Journal: | BRITISH JOURNAL OF DERMATOLOGY | Volumen: | 176 | Ausgabe: | 6 | Startseite: | 1533 | Seitenende: | 1540 | Zusammenfassung: | Background Recent studies have demonstrated allergen-specific differences in the gene expression of inflammatory mediators in patch tested skin. Objectives To determine levels of various inflammatory mediators in the stratum corneum (SC) after patch testing with common contact allergens and the skin irritant sodium lauryl sulfate (SLS). Methods In total, 27 individuals who had previously patch tested positive to nickel, chromium, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) or para-phenylenediamine were retested and then patch tested with SLS and petrolatum, with petrolatum serving as the patch test control. At 72 h, the test sites were clinically graded and the SC samples collected on adhesive tape. Results The levels of 18 of the 32 quantified mediators differed significantly from that of the control patches for at least one of the tested substances. SLS and MCI/MI induced the largest number of immunomediators. Interleukin (IL)-16 levels were significantly higher in patch test reactions in all allergens than they were in the controls, while no significant difference was detected for SLS. Furthermore, a strong negative correlation was found between strength of patch test reaction and IL-1 alpha levels. Conclusions Cytokine profiles in the SC of patch tested skin did not show a distinct allergen-specific pattern. However, MCI/MI induced a larger and wider immune response than the other allergens, perhaps due to its potency as an irritant. The levels of IL-16 were significantly increased in patch test reactions to allergens but not to SLS; thus, they may help clinicians to differentiate between allergic contact dermatitis and irritant contact dermatitis. |
ISSN: | 00070963 | DOI: | 10.1111/bjd.15163 |
Zur Langanzeige
Seitenaufrufe
4
Letzte Woche
0
0
Letzter Monat
0
0
geprüft am 01.06.2024