Sensitization to reactive diluents and hardeners in epoxy resin systems. IVDK data 2002-2011. Part II: concomitant reactions
Autor(en): | Geier, Johannes Lessmann, Holger Hillen, Uwe Skudlik, Christoph Jappe, Uta |
Stichwörter: | Allergy; concomitant reactivity; CONTACT ALLERGY; cross-reactivity; DERMATITIS; Dermatology; epoxy resin systems; hardeners; MAXIMIZATION TEST; occupational contact allergy; reactive diluents | Erscheinungsdatum: | 2016 | Herausgeber: | WILEY-BLACKWELL | Journal: | CONTACT DERMATITIS | Volumen: | 74 | Ausgabe: | 2 | Startseite: | 94 | Seitenende: | 101 | Zusammenfassung: | Background. Beside the basic resins, reactive diluents and hardeners are important sensitizers in epoxy resin systems (ERSs). Because of chemical similarities, immunological cross-reactivity may occur. Objectives. To analyse concomitant reactivity among reactive diluents and hardeners in the patients concerned, as one integral part of a research project on the sensitizing capacity of ERSs (FP-0324). Methods. Aretrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 2002-2011, was performed. Results. There was close concomitant reactivity to 1,6-hexanediol diglycidyl ether and 1,4-butanediol diglycidyl ether (1,4-BDDGE), and to phenyl glycidyl ether (PGE) and cresyl glycidyl ether (CGE), whereas reactions to p-tert-butylphenyl glycidyl ether occurred more independently from those to PGE and CGE. Concomitant reactions to butyl glycidyl ether and 1,4-BDDGE may point to a common allergenic compound derived from the metabolism of 1,4-BDDGE. Among the structurally more diverse group of hardeners, there was no evidence of immunological cross-reactions. Conclusions. More detailed knowledge of cross-reactivity among ERS components facilitates the interpretation of patch test results and will allow safer ERSs to be composed in the future. |
ISSN: | 01051873 | DOI: | 10.1111/cod.12490 |
Zur Langanzeige
Seitenaufrufe
1
Letzte Woche
0
0
Letzter Monat
0
0
geprüft am 02.05.2024