Context Matters: The Illusive Simplicity of Macaque V1 Receptive Fields
DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Haslinger, Robert | |
dc.contributor.author | Pipa, Gordon | |
dc.contributor.author | Lima, Bruss | |
dc.contributor.author | Singer, Wolf | |
dc.contributor.author | Brown, Emery N. | |
dc.contributor.author | Neuenschwander, Sergio | |
dc.date.accessioned | 2021-12-23T16:22:13Z | - |
dc.date.available | 2021-12-23T16:22:13Z | - |
dc.date.issued | 2012 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/14215 | - |
dc.description.abstract | Even in V1, where neurons have well characterized classical receptive fields (CRFs), it has been difficult to deduce which features of natural scenes stimuli they actually respond to. Forward models based upon CRF stimuli have had limited success in predicting the response of V1 neurons to natural scenes. As natural scenes exhibit complex spatial and temporal correlations, this could be due to surround effects that modulate the sensitivity of the CRF. Here, instead of attempting a forward model, we quantify the importance of the natural scenes surround for awake macaque monkeys by modeling it non-parametrically. We also quantify the influence of two forms of trial to trial variability. The first is related to the neuron's own spike history. The second is related to ongoing mean field population activity reflected by the local field potential (LFP). We find that the surround produces strong temporal modulations in the firing rate that can be both suppressive and facilitative. Further, the LFP is found to induce a precise timing in spikes, which tend to be temporally localized on sharp LFP transients in the gamma frequency range. Using the pseudo R 2 as a measure of model fit, we find that during natural scene viewing the CRF dominates, accounting for 60% of the fit, but that taken collectively the surround, spike history and LFP are almost as important, accounting for 40%. However, overall only a small proportion of V1 spiking statistics could be explained (R-2 similar to 5%), even when the full stimulus, spike history and LFP were taken into account. This suggests that under natural scene conditions, the dominant influence on V1 neurons is not the stimulus, nor the mean field dynamics of the LFP, but the complex, incoherent dynamics of the network in which neurons are embedded. | |
dc.description.sponsorship | National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [K25 NS052422-02, DP1 ODOO3646]; European UnionEuropean Commission [FP6-2005-NEST-Path-043309]; EC Project Phocus [240763]; Max Planck SocietyMax Planck SocietyFoundation CELLEX; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [K25NS052422] Funding Source: NIH RePORTER; OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [DP1OD003646] Funding Source: NIH RePORTER; This work was supported by National Institutes of Health grants K25 NS052422-02 (RH), and DP1 ODOO3646 (EB), as well as European Union Grant FP6-2005-NEST-Path-043309 (GP), EC Project Phocus Grant 240763 (GP) and the Max Planck Society (GP, BL, WS, SN). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | |
dc.language.iso | en | |
dc.publisher | PUBLIC LIBRARY SCIENCE | |
dc.relation.ispartof | PLOS ONE | |
dc.subject | CELL PROPERTIES | |
dc.subject | CORTICAL-NEURONS | |
dc.subject | GAMMA-BAND SYNCHRONIZATION | |
dc.subject | Multidisciplinary Sciences | |
dc.subject | NATURAL SCENES | |
dc.subject | NEURONAL CIRCUITS | |
dc.subject | PRIMARY VISUAL-CORTEX | |
dc.subject | RESPONSE VARIABILITY | |
dc.subject | Science & Technology - Other Topics | |
dc.subject | SPIKING ACTIVITY | |
dc.subject | STRIATE CORTEX | |
dc.subject | TIME-RESCALING THEOREM | |
dc.title | Context Matters: The Illusive Simplicity of Macaque V1 Receptive Fields | |
dc.type | journal article | |
dc.identifier.doi | 10.1371/journal.pone.0039699 | |
dc.identifier.isi | ISI:000306186900014 | |
dc.description.volume | 7 | |
dc.description.issue | 7 | |
dc.contributor.orcid | 0000-0002-3416-2652 | |
dc.contributor.orcid | 0000-0001-6865-2900 | |
dc.contributor.orcid | 0000-0001-7493-121X | |
dc.contributor.researcherid | M-1813-2014 | |
dc.contributor.researcherid | I-9164-2016 | |
dc.contributor.researcherid | D-6874-2012 | |
dc.publisher.place | 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA | |
dcterms.isPartOf.abbreviation | PLoS One | |
dcterms.oaStatus | Green Published, gold, Green Submitted | |
crisitem.author.dept | Institut für Kognitionswissenschaft | - |
crisitem.author.deptid | institute28 | - |
crisitem.author.orcid | 0000-0002-3416-2652 | - |
crisitem.author.parentorg | FB 08 - Humanwissenschaften | - |
crisitem.author.grandparentorg | Universität Osnabrück | - |
crisitem.author.netid | PiGo340 | - |
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geprüft am 05.05.2024