DC Field | Value | Language |
dc.contributor.author | Bergmann, Johanna | |
dc.contributor.author | Pilatus, Ulrich | |
dc.contributor.author | Genc, Erhan | |
dc.contributor.author | Kohler, Axel | |
dc.contributor.author | Singer, Wolf | |
dc.contributor.author | Pearson, Joel | |
dc.date.accessioned | 2021-12-23T16:22:44Z | - |
dc.date.available | 2021-12-23T16:22:44Z | - |
dc.date.issued | 2016 | |
dc.identifier.issn | 10538119 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/14289 | - |
dc.description.abstract | A number of recent studies have established a link between behavior and the anatomy of the primary visual cortex (V1). However, one often-raised criticism has been that these studies provide little insight into the mechanisms of the observed relationships. As inhibitory neural interactions have been postulated as an important mechanism for those behaviors related to V1 anatomy, we measured the concentration of inhibitory gammaamino butyric acid (GABA) in the medial occipital cortex where V1 is located using magnetic resonance spectroscopy (MRS) and estimated the surface area of V1 using fMRI retinotopic mapping. We found a significant positive relationship between GABA concentration and V1 surface area. This relationship was present irrespective of whether the MRS voxel had a fixed size across participants or was proportionally sized to each individual's V1 surface area. Hence, individuals with a larger V1 had a higher GABA concentration in the medial occipital cortex. By tying together V1 size and GABA concentration, our findings point towards individual differences in the level of neural inhibition that might partially mediate the relationships between behavior and V1 neuroanatomy. In addition, they illustrate how stable microscopic properties of neural activity and function are reflected in macro-measures of V1 structure. (C) 2015 Elsevier Inc. All rights reserved. | |
dc.description.sponsorship | Australian NHMRC projectNational Health and Medical Research Council of Australia [APP1024800, APP1046198]; ARCAustralian Research Council [DP140101560]; Career Development Fellowship [APP1049596]; International Postgraduate Research ScholarshipAustralian Government; Brain Sciences UNSW PhD Top Up Scholarship; Australian NHMRC projectNational Health and Medical Research Council of Australia [APP1024800, APP1046198]; ARCAustralian Research Council [DP140101560]; Career Development Fellowship [APP1049596]; International Postgraduate Research ScholarshipAustralian Government; Brain Sciences UNSW PhD Top Up Scholarship; This work was supported by Australian NHMRC project grants APP1024800 and APP1046198, ARC grant DP140101560 and a Career Development Fellowship (APP1049596) held by JP. J.B. was supported by an International Postgraduate Research Scholarship and a Brain Sciences UNSW PhD Top Up Scholarship. | |
dc.language.iso | en | |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | |
dc.relation.ispartof | NEUROIMAGE | |
dc.subject | 3 T | |
dc.subject | CEREBRAL-CORTEX | |
dc.subject | COORDINATE SYSTEM | |
dc.subject | CORTICAL SURFACE | |
dc.subject | GABA concentration | |
dc.subject | GAMMA-AMINOBUTYRIC-ACID | |
dc.subject | Individual differences | |
dc.subject | MAGNETIC-RESONANCE-SPECTROSCOPY | |
dc.subject | MENSTRUAL-CYCLE | |
dc.subject | Neuroimaging | |
dc.subject | Neurosciences | |
dc.subject | Neurosciences & Neurology | |
dc.subject | ORIENTATION SENSITIVITY | |
dc.subject | Primary visual cortex surface area | |
dc.subject | PRIMARY VISUAL-CORTEX | |
dc.subject | Radiology, Nuclear Medicine & Medical Imaging | |
dc.subject | RESTING GABA | |
dc.title | V1 surface size predicts GABA concentration in medial occipital cortex | |
dc.type | journal article | |
dc.identifier.doi | 10.1016/j.neuroimage.2015.09.036 | |
dc.identifier.isi | ISI:000366646700060 | |
dc.description.volume | 124 | |
dc.description.issue | A | |
dc.description.startpage | 654 | |
dc.description.endpage | 662 | |
dc.contributor.orcid | 0000-0001-6514-5479 | |
dc.contributor.orcid | 0000-0003-0196-973X | |
dc.contributor.orcid | 0000-0003-1968-9680 | |
dc.contributor.orcid | 0000-0003-3704-5037 | |
dc.contributor.researcherid | T-9376-2018 | |
dc.contributor.researcherid | B-1738-2010 | |
dc.contributor.researcherid | D-6874-2012 | |
dc.identifier.eissn | 10959572 | |
dc.publisher.place | 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA | |
dcterms.isPartOf.abbreviation | Neuroimage | |