Polynuclear zinc(II) complexes of thiosemicarbazone: Synthesis, X-ray structure and biological evaluation

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dc.contributor.authorSaswati
dc.contributor.authorMohanty, Monalisa
dc.contributor.authorBanerjee, Atanu
dc.contributor.authorBiswal, Sonaleen
dc.contributor.authorHorn, Jr., Adolfo
dc.contributor.authorSchenk, Gerhard
dc.contributor.authorBrzezinski, Krzysztof
dc.contributor.authorSinn, Ekkehard
dc.contributor.authorReuter, Hans
dc.contributor.authorDinda, Rupam
dc.date.accessioned2021-12-23T16:22:51Z-
dc.date.available2021-12-23T16:22:51Z-
dc.date.issued2020
dc.identifier.issn01620134
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/14329-
dc.description.abstractTwo new dimeric Zn(II) ([{ZnL1(DMSO2)}(2)]center dot DMSO (1), [{(ZnLCl)-Cl-2}(2)] (2)) and a novel tetrameric Zn(II) complex ([(Zn2L3)(2)(mu-OAc)(2)(mu(3)-O)(2)] (3)), where H2L1 = 4-(p-methoxyphenyl) thiosemicarbazone of o-hydroxynapthaldehyde, HL2 = 4-(p-methoxyphenyl)thiosemicarbazone of benzoyl pyridine and H2L3 = 4-(p-chlorophenyl)thiosemicarbazone of o-vanillin are reported. Ligands and their complexes were characterized by spectroscopic and single crystal X-ray diffraction techniques. In addition, the complexes exhibited good binding affinity towards HSA (10(12)M(-1)), which is supported by their ability to quench the tryptophan fluorescence emission spectra of HSA. The complexes were also screened for their DNA binding propensity through UV-vis absorption titration, circular dichroism and fluorescence spectral studies. Results show that they effectively interact with CT-DNA through an intercalative mode of binding, with binding constants ranging from 10(3) to 10(4) M-1. Among the three complexes 1 has the highest binding affinity towards CT-DNA. Further, the phosphatase activity was evaluated using bis(2,4-dinitrophenyl)phosphate (BDNPP) as substrate, however, the complexes did not yield any measurable catalytic activity. Nevertheless the complexes showed significant cytotoxic potential against HeLa and HT-29 cancer cell lines that was assessed through MTT assay and DAPI staining. Remarkably, complex 1 showed better activity than cisplatin against HT-29 cell line.
dc.description.sponsorshipDBT, Govt. [6242-Pi 12/RGCB/PMD/DBT/RPDA/2015]; CSIRCouncil of Scientific & Industrial Research (CSIR) - India [01(2963)/18/EMR-II]; R.D. thanks DBT, Govt. of India [Grant No. 6242-Pi 12/RGCB/PMD/DBT/RPDA/2015] and CSIR, Govt. of India [Grant No. 01(2963)/18/EMR-II] for funding this research. R. D. also thanks Prof. Sujit K. Bhutia for fruitful discussion related to biological study.
dc.language.isoen
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofJOURNAL OF INORGANIC BIOCHEMISTRY
dc.subject3-AMINOPYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE
dc.subjectBiochemistry & Molecular Biology
dc.subjectChemistry
dc.subjectChemistry, Inorganic & Nuclear
dc.subjectCYTOTOXIC ACTIVITIES
dc.subjectCytotoxicity
dc.subjectDNA and HSA interaction
dc.subjectDNA CLEAVAGE
dc.subjectIN-VITRO
dc.subjectPHASE-II
dc.subjectPhosphoesterase activity
dc.subjectPolynuclear zinc(II) complexes
dc.subjectRIBONUCLEOTIDE REDUCTASE
dc.subjectRUTHENIUM(II) ARENE COMPLEXES
dc.subjectSPECTRAL CHARACTERIZATION
dc.subjectThiosemicarbazone
dc.subjectVITRO ANTICANCER ACTIVITY
dc.subjectZN(II) COMPLEXES
dc.titlePolynuclear zinc(II) complexes of thiosemicarbazone: Synthesis, X-ray structure and biological evaluation
dc.typejournal article
dc.identifier.doi10.1016/j.jinorgbio.2019.110908
dc.identifier.isiISI:000510109900013
dc.description.volume203
dc.contributor.orcid0000-0001-9339-7745
dc.contributor.orcid0000-0001-9155-9093
dc.contributor.orcid0000-0001-7815-4593
dc.contributor.orcid0000-0001-8619-0631
dc.contributor.researcheridR-8406-2019
dc.contributor.researcheridA-8451-2008
dc.identifier.eissn18733344
dc.publisher.placeSTE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
dcterms.isPartOf.abbreviationJ. Inorg. Biochem.
crisitem.author.deptInstitut für Chemie neuer Materialien-
crisitem.author.deptidinstitute11-
crisitem.author.parentorgFB 05 - Biologie/Chemie-
crisitem.author.grandparentorgUniversität Osnabrück-
crisitem.author.netidReHa636-
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