Polynuclear zinc(II) complexes of thiosemicarbazone: Synthesis, X-ray structure and biological evaluation
DC Element | Wert | Sprache |
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dc.contributor.author | Saswati | |
dc.contributor.author | Mohanty, Monalisa | |
dc.contributor.author | Banerjee, Atanu | |
dc.contributor.author | Biswal, Sonaleen | |
dc.contributor.author | Horn, Jr., Adolfo | |
dc.contributor.author | Schenk, Gerhard | |
dc.contributor.author | Brzezinski, Krzysztof | |
dc.contributor.author | Sinn, Ekkehard | |
dc.contributor.author | Reuter, Hans | |
dc.contributor.author | Dinda, Rupam | |
dc.date.accessioned | 2021-12-23T16:22:51Z | - |
dc.date.available | 2021-12-23T16:22:51Z | - |
dc.date.issued | 2020 | |
dc.identifier.issn | 01620134 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/14329 | - |
dc.description.abstract | Two new dimeric Zn(II) ([{ZnL1(DMSO2)}(2)]center dot DMSO (1), [{(ZnLCl)-Cl-2}(2)] (2)) and a novel tetrameric Zn(II) complex ([(Zn2L3)(2)(mu-OAc)(2)(mu(3)-O)(2)] (3)), where H2L1 = 4-(p-methoxyphenyl) thiosemicarbazone of o-hydroxynapthaldehyde, HL2 = 4-(p-methoxyphenyl)thiosemicarbazone of benzoyl pyridine and H2L3 = 4-(p-chlorophenyl)thiosemicarbazone of o-vanillin are reported. Ligands and their complexes were characterized by spectroscopic and single crystal X-ray diffraction techniques. In addition, the complexes exhibited good binding affinity towards HSA (10(12)M(-1)), which is supported by their ability to quench the tryptophan fluorescence emission spectra of HSA. The complexes were also screened for their DNA binding propensity through UV-vis absorption titration, circular dichroism and fluorescence spectral studies. Results show that they effectively interact with CT-DNA through an intercalative mode of binding, with binding constants ranging from 10(3) to 10(4) M-1. Among the three complexes 1 has the highest binding affinity towards CT-DNA. Further, the phosphatase activity was evaluated using bis(2,4-dinitrophenyl)phosphate (BDNPP) as substrate, however, the complexes did not yield any measurable catalytic activity. Nevertheless the complexes showed significant cytotoxic potential against HeLa and HT-29 cancer cell lines that was assessed through MTT assay and DAPI staining. Remarkably, complex 1 showed better activity than cisplatin against HT-29 cell line. | |
dc.description.sponsorship | DBT, Govt. [6242-Pi 12/RGCB/PMD/DBT/RPDA/2015]; CSIRCouncil of Scientific & Industrial Research (CSIR) - India [01(2963)/18/EMR-II]; R.D. thanks DBT, Govt. of India [Grant No. 6242-Pi 12/RGCB/PMD/DBT/RPDA/2015] and CSIR, Govt. of India [Grant No. 01(2963)/18/EMR-II] for funding this research. R. D. also thanks Prof. Sujit K. Bhutia for fruitful discussion related to biological study. | |
dc.language.iso | en | |
dc.publisher | ELSEVIER SCIENCE INC | |
dc.relation.ispartof | JOURNAL OF INORGANIC BIOCHEMISTRY | |
dc.subject | 3-AMINOPYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE | |
dc.subject | Biochemistry & Molecular Biology | |
dc.subject | Chemistry | |
dc.subject | Chemistry, Inorganic & Nuclear | |
dc.subject | CYTOTOXIC ACTIVITIES | |
dc.subject | Cytotoxicity | |
dc.subject | DNA and HSA interaction | |
dc.subject | DNA CLEAVAGE | |
dc.subject | IN-VITRO | |
dc.subject | PHASE-II | |
dc.subject | Phosphoesterase activity | |
dc.subject | Polynuclear zinc(II) complexes | |
dc.subject | RIBONUCLEOTIDE REDUCTASE | |
dc.subject | RUTHENIUM(II) ARENE COMPLEXES | |
dc.subject | SPECTRAL CHARACTERIZATION | |
dc.subject | Thiosemicarbazone | |
dc.subject | VITRO ANTICANCER ACTIVITY | |
dc.subject | ZN(II) COMPLEXES | |
dc.title | Polynuclear zinc(II) complexes of thiosemicarbazone: Synthesis, X-ray structure and biological evaluation | |
dc.type | journal article | |
dc.identifier.doi | 10.1016/j.jinorgbio.2019.110908 | |
dc.identifier.isi | ISI:000510109900013 | |
dc.description.volume | 203 | |
dc.contributor.orcid | 0000-0001-9339-7745 | |
dc.contributor.orcid | 0000-0001-9155-9093 | |
dc.contributor.orcid | 0000-0001-7815-4593 | |
dc.contributor.orcid | 0000-0001-8619-0631 | |
dc.contributor.researcherid | R-8406-2019 | |
dc.contributor.researcherid | A-8451-2008 | |
dc.identifier.eissn | 18733344 | |
dc.publisher.place | STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA | |
dcterms.isPartOf.abbreviation | J. Inorg. Biochem. | |
crisitem.author.dept | Institut für Chemie neuer Materialien | - |
crisitem.author.deptid | institute11 | - |
crisitem.author.parentorg | FB 05 - Biologie/Chemie | - |
crisitem.author.grandparentorg | Universität Osnabrück | - |
crisitem.author.netid | ReHa636 | - |
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geprüft am 07.06.2024