Integrin alpha(E)(CD103) Is Involved in Regulatory T-Cell Function in Allergic Contact Hypersensitivity

Autor(en): Braun, Andrea
Dewert, Nadin
Brunnert, Fiona
Schnabel, Viktor
Hardenberg, Jan-Hendrik
Richter, Beatrice
Zachmann, Karolin
Cording, Sascha
Classen, Anna
Brans, Richard 
Hamann, Alf
Huehn, Jochen
Schoen, Michael P.
Stichwörter: CD103; DENDRITIC CELLS; Dermatology; DIFFERENTIATION; E-CADHERIN; EFFECTOR; EPITHELIAL-CELLS; LANGERHANS CELLS; LYMPHOCYTES; MECHANISMS; SPECIFICATION
Erscheinungsdatum: 2015
Herausgeber: ELSEVIER SCIENCE INC
Journal: JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volumen: 135
Ausgabe: 12
Startseite: 2982
Seitenende: 2991
Zusammenfassung: 
Murine contact hypersensitivity (CHS) is a dendritic cell (DC)-dependent T-cell-mediated inflammation with CD8(+) T cells as effectors and CD4(+) T cells as regulators (Treg cells) that models human allergic contact dermatitis. The integrin alpha(E)(CD103) is expressed by some T-cell and DC subsets and has been implicated in epithelial lymphocyte localization, but its role in immune regulation remains enigmatic. We have identified a function for CD103 in the development of cutaneous allergic immune responses. CHS responses, but not irritant contact dermatitis, were significantly augmented in CD103-deficient mice in hapten-challenged skin. Phenotype and function of skin DCs during sensitization were normal, whereas adoptive transfer experiments revealed that the elevated CHS response in CD103-deficient mice is transferred by primed T cells and is independent of resident cells in recipient mice. While T-cell counts were elevated in challenged skin of CD103-deficient mice, the FoxP3 expression level of CD4(+)CD25(+) Treg cells was significantly reduced, indicating impaired functionality. Indeed, Treg cells from CD103-deficient mice were not able to suppress CHS reactions during the elicitation phase. Further, CD103 on FoxP3(+) Treg cells was involved in Treg retention to inflamed skin. These findings indicate an unexpected dichotomous functional role for CD103 on Treg cells by modulating FoxP3 expression.
ISSN: 0022202X
DOI: 10.1038/jid.2015.287

Show full item record

Page view(s)

2
Last Week
0
Last month
1
checked on Feb 24, 2024

Google ScholarTM

Check

Altmetric