Anionic Dinuclear Oxidovanadium(IV) Complexes with Azo Functionalized Tridentate Ligands and mu-Ethoxido Bridge Leading to an Unsymmetric Twisted Arrangement: Synthesis, X-ray Structure, Magnetic Properties, and Cytotoxicity

DC FieldValueLanguage
dc.contributor.authorRoy, Satabdi
dc.contributor.authorBoehme, Michael
dc.contributor.authorDash, Subhashree P.
dc.contributor.authorMohanty, Monalisa
dc.contributor.authorBuchholz, Axel
dc.contributor.authorPlass, Winfried
dc.contributor.authorMajumder, Sudarshana
dc.contributor.authorKulanthaivel, Senthilguru
dc.contributor.authorBanerjee, Indranil
dc.contributor.authorReuter, Hans
dc.contributor.authorKaminsky, Werner
dc.contributor.authorDinda, Rupam
dc.date.accessioned2021-12-23T16:23:13Z-
dc.date.available2021-12-23T16:23:13Z-
dc.date.issued2018
dc.identifier.issn00201669
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/14461-
dc.description.abstractThe synthesis of ethoxido-bridged dinuclear oxidovanadium(IV) complexes of the general formula (HNEt3)[(VOL1-3)(2)(mu-OEt)] (1-3) with the azo dyes 2-(2'-carboxy-5'-X-phenylazo)-4-methylphenol (H2L1, X = H; H2L2, X = NO2) and 2-(2'-carboxy-5'-Br-phenylazo)-2-naphthol (H2L3) as ligands is reported. The ligands differ in the substituents at the phenyl ring to probe their influence on the redox behavior, biological activity, and magnetochemistry of the complexes, for which the results are presented and discussed. All synthesized ligands and vanadium(IV) complexes have been characterized by various physicochemical techniques, namely, elemental analysis, electrospray ionization mass spectrometry, spectroscopic methods (UV/vis and IR), and cyclic voltammetry. X-ray crystallography of 1 and 3 revealed the presence of a twisted arrangement of the edged-shared bridging core unit. In agreement with the distorted nature of the twisted core, antiferromagnetic exchange interactions were observed between the vanadium (IV) centers of the dinuclear complexes with a superexchange mechanism operative. These results have been verified by DFT calculations. The complexes were also screened for their in vitro cytotoxicity against HeLa and HT-29 cancer cell lines. The results indicated that all the synthesized vanadium(IV) complexes (1-3) were cytotoxic in nature and were specific to a particular cell type. Complex 1 was found to be the most potent against HeLa cells (IC50 value 1.92 mu M).
dc.description.sponsorshipDBT, Govt. of IndiaDepartment of Biotechnology (DBT) India [6241 P112/RGCB/PMD/DBT/RPDA/2015]; Council of Scientific and Industrial Research, New DelhiCouncil of Scientific & Industrial Research (CSIR) - India [01(2735)/13/EMR-II]; The authors thank the reviewers for their comments and suggestions, which were helpful in preparing the revised version of the manuscript. RD. thanks Prof. S. K. Chattopadhyay for discussion and electrochemical study. RD. thanks DBT, Govt. of India [Grant No. 6241 P112/RGCB/PMD/DBT/RPDA/2015] and Council of Scientific and Industrial Research, New Delhi [Grant No. 01(2735)/13/EMR-II] for funding this research.
dc.language.isoen
dc.publisherAMER CHEMICAL SOC
dc.relation.ispartofINORGANIC CHEMISTRY
dc.subjectANTICANCER DRUGS
dc.subjectBASIS-SETS
dc.subjectChemistry
dc.subjectChemistry, Inorganic & Nuclear
dc.subjectCRYSTAL-STRUCTURE
dc.subjectHYDROGEN-BONDING RELAYS
dc.subjectMAGNETOSTRUCTURAL CORRELATIONS
dc.subjectMODELING SUPRAMOLECULAR INTERACTIONS
dc.subjectNON-OXIDO VANADIUM(IV)
dc.subjectOXOVANADIUM(IV) COMPLEXES
dc.subjectPHOTOINDUCED DNA CLEAVAGE
dc.subjectSOLID-STATE
dc.titleAnionic Dinuclear Oxidovanadium(IV) Complexes with Azo Functionalized Tridentate Ligands and mu-Ethoxido Bridge Leading to an Unsymmetric Twisted Arrangement: Synthesis, X-ray Structure, Magnetic Properties, and Cytotoxicity
dc.typejournal article
dc.identifier.doi10.1021/acs.inorgchem.8b00035
dc.identifier.isiISI:000433013600009
dc.description.volume57
dc.description.issue10
dc.description.startpage5767
dc.description.endpage5781
dc.contributor.orcid0000-0001-9452-7791
dc.contributor.orcid0000-0002-9100-4909
dc.contributor.orcid0000-0003-3634-8765
dc.contributor.orcid0000-0003-2097-4657
dc.contributor.researcheridN-5995-2017
dc.contributor.researcheridAAF-2578-2020
dc.identifier.eissn1520510X
dc.publisher.place1155 16TH ST, NW, WASHINGTON, DC 20036 USA
dcterms.isPartOf.abbreviationInorg. Chem.
crisitem.author.deptInstitut für Chemie neuer Materialien-
crisitem.author.deptidinstitute11-
crisitem.author.parentorgFB 05 - Biologie/Chemie-
crisitem.author.grandparentorgUniversität Osnabrück-
crisitem.author.netidReHa636-
Show simple item record

Page view(s)

1
Last Week
0
Last month
0
checked on Jun 24, 2024

Google ScholarTM

Check

Altmetric