Patch testing with components of water-based metalworking fluids: results of a multicentre study with a second series
DC Element | Wert | Sprache |
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dc.contributor.author | Geier, Johannes | |
dc.contributor.author | Lessmann, Holger | |
dc.contributor.author | Becker, Detlef | |
dc.contributor.author | Bruze, Magnus | |
dc.contributor.author | Frosch, Peter J. | |
dc.contributor.author | Fuchs, Thomas | |
dc.contributor.author | Jappe, Uta | |
dc.contributor.author | Koch, Patrick | |
dc.contributor.author | Pfoehler, Claudia | |
dc.contributor.author | Skudlik, Christoph | |
dc.date.accessioned | 2021-12-23T16:23:19Z | - |
dc.date.available | 2021-12-23T16:23:19Z | - |
dc.date.issued | 2006 | |
dc.identifier.issn | 01051873 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/14496 | - |
dc.description.abstract | Background: Although many allergens in metalworking fluids (MWF) are identified, there are still some MWF components, which are not sufficiently investigated concerning their sensitizing properties. Objectives: To investigate sensitization to 10 frequently used MWF components, which are not part of the established MWF test series, in metalworkers with suspected occupational dermatitis due to MWF. Patients/Methods: Oleyl alcohol, myristyl alcohol, dimethylolurea, 4,4'-methylenebis morpholine, imazalil, 1-amino-2-propanol (monoisopropanolamine; MIPA), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2,5-bis(n-octyldithio)-1,3,4-thiadiazole, zinc alkyl dithiophosphate and dibenzyl disulfide have been patch tested in 144 patients. Results: 7 patients reacted positively to the formaldehyde releaser 4,4'-methylenebis morpholine, and 6 of these patients also reacted to formaldehyde and/or other formaldehyde releasers. 4 patients reacted positively to myristyl alcohol tested at 10% petrolatum (pet.). Additionally, 20 doubtful or irritant reactions occurred. 1 patient each reacted positively to oleyl alcohol, MIRA, and AEPD. None of the other test substances mentioned above elicited any clear-cut positive reaction. Patch testing with well-known MWF allergens showed proportions of positive reactions, which were comparable to those from other studies, e.g. 11% to monoethanolamine, 8% to colophonium and 3%-5% to various preservatives. Conclusions: 4,4'-methylenebis morpholine may be an important MWF allergen, although clinical relevance could not be stated definitely in every case. Myristyl alcohol should not be patch tested at 10% pet., but at a lesser concentration, due to irritant properties. | |
dc.language.iso | en | |
dc.publisher | BLACKWELL PUBLISHING | |
dc.relation.ispartof | CONTACT DERMATITIS | |
dc.subject | 1-amino-2-propanol (monoisopropanolamine | |
dc.subject | 2-amino-2-ethyl-1,3-propanediol (AEPD) | |
dc.subject | 4,4 `-methylenebis morpholine | |
dc.subject | ALLERGIC CONTACT-DERMATITIS | |
dc.subject | Allergy | |
dc.subject | contact allergy | |
dc.subject | Dermatology | |
dc.subject | DITHIOPHOSPHATE | |
dc.subject | formaldehyde | |
dc.subject | metalworking fluids | |
dc.subject | MIPA) | |
dc.subject | myristyl alcohol | |
dc.subject | occupational | |
dc.subject | OLEYL ALCOHOL | |
dc.subject | patch testing | |
dc.title | Patch testing with components of water-based metalworking fluids: results of a multicentre study with a second series | |
dc.type | journal article | |
dc.identifier.doi | 10.1111/j.1600-0536.2006.00993.x | |
dc.identifier.isi | ISI:000242532300002 | |
dc.description.volume | 55 | |
dc.description.issue | 6 | |
dc.description.startpage | 322 | |
dc.description.endpage | 329 | |
dc.contributor.researcherid | AAD-1031-2019 | |
dc.publisher.place | 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND | |
dcterms.isPartOf.abbreviation | Contact Dermatitis | |
crisitem.author.dept | Universität Osnabrück | - |
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