Chemistry of mixed-ligand oxidovanadium(IV) complexes of aroylhydrazones incorporating quinoline derivatives: Study of solution behavior, theoretical evaluation and protein/DNA interaction

DC FieldValueLanguage
dc.contributor.authorBanerjee, Atanu
dc.contributor.authorDash, Subhashree P.
dc.contributor.authorMohanty, Monalisa
dc.contributor.authorSanna, Daniele
dc.contributor.authorSciortino, Giuseppe
dc.contributor.authorUgone, Valeria
dc.contributor.authorGarribba, Eugenio
dc.contributor.authorReuter, Hans
dc.contributor.authorKaminsky, Werner
dc.contributor.authorDinda, Rupam
dc.date.accessioned2021-12-23T16:23:36Z-
dc.date.available2021-12-23T16:23:36Z-
dc.date.issued2019
dc.identifier.issn01620134
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/14596-
dc.description.abstractA series of eight hexacoordinated mixed-ligand oxidovanadium(IV) complexes [VO(L-x)(LN-N)] (1-8), where L-x = L-1 - L-4 are four differently substituted ONO donor aroylhydrazone ligands and LN-N are N,N-donor bases like 2,2'-bipyridine (bipy) (1, 3, 5 and 7) and 1,10-phenanthroline (phen) (2, 4, 6 and 8), have been reported. All synthesized complexes have been characterized by various physicochemical techniques and molecular structures of 1 and 6 were determined by X-ray crystallography. With a view to evaluate the biological activity of the (VO)-O-IV species, the behavior of the systems (VO2+)-O-IV/L-x, (VO2+)-O-IV/L-x/bipy and (VO2+)-O-IV/L-x/phen was studied as a function of pH in a mixture of H2O/DMSO 50/50 (v/v). DFT calculations allowed finding out the relative stability of the tautomeric forms of the ligands, and predicting the structure of vanadium complexes and their EPR parameters. To study their interaction with proteins, firstly the ternary systems (VO2+)-O-IV/L-1,L-2 with 1-methylimidazole, which is a good model for histidine binding, were examined. Subsequently the interaction of the complexes with lysozyme (Lyz), cytochrome c (Cyt) and bovine serum albumin (BSA) was studied. The results indicate that the complexes showed moderate binding affinity towards BSA, while no interaction takes place with lysozyme and cytochrome c. This could be explained with the higher number of accessible coordinating and polar residues for BSA than for Lyz and Cyt. Further, the complexes were also evaluated for their DNA binding propensity through UV-vis absorption titration and fluorescence spectral studies. These results were consistent with BSA binding affinity and showed moderate binding affinity towards CT-DNA.
dc.description.sponsorshipDBT, Govt. of IndiaDepartment of Biotechnology (DBT) India [6242 P112/RGCB/PMD/DBT/RPDA/2015]; Fondazione di SardegnaFondazione Banco di Sardegna [FDS15Garribba]; Regione Autonoma della SardegnaRegione Sardegna [RASSR79857]; Spanish MINECOSpanish Government [CTQ2017-87889-P]; Generalitat de CatalunyaGeneralitat de CatalunyaGeneral Electric [2017SGR1323]; Universitat Autonoma de Barcelona; R.D thanks DBT, Govt. of India [Grant No. 6242 P112/RGCB/PMD/DBT/RPDA/2015] for funding this research. D.S., V.U., G.S. and E.G. thank Fondazione di Sardegna (project FDS15Garribba) and Regione Autonoma della Sardegna (grant RASSR79857) for the financial support. G.S. thanks also Spanish MINECO (grant CTQ2017-87889-P) and Generalitat de Catalunya (2017SGR1323) and the Universitat Autonoma de Barcelona for its support to his Ph.D.
dc.language.isoen
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofJOURNAL OF INORGANIC BIOCHEMISTRY
dc.subject(VO)-O-IV COMPLEXES
dc.subjectAroylhydrazone
dc.subjectBiochemistry & Molecular Biology
dc.subjectBLOOD-PLASMA
dc.subjectChemistry
dc.subjectChemistry, Inorganic & Nuclear
dc.subjectDFT calculations
dc.subjectDNA binding
dc.subjectHYPERFINE COUPLING-CONSTANTS
dc.subjectIN-VITRO
dc.subjectINSULIN-MIMETIC ACTIVITY
dc.subjectMixed-ligand oxidovanadium(IV)
dc.subjectNON-OXIDO VANADIUM(IV)
dc.subjectPHOTOINDUCED DNA CLEAVAGE
dc.subjectProtein interaction
dc.subjectSPECTROSCOPIC CHARACTERIZATION
dc.subjectTRANSITION-METAL-COMPLEXES
dc.subjectVANADYL COMPLEXES
dc.titleChemistry of mixed-ligand oxidovanadium(IV) complexes of aroylhydrazones incorporating quinoline derivatives: Study of solution behavior, theoretical evaluation and protein/DNA interaction
dc.typejournal article
dc.identifier.doi10.1016/j.jinorgbio.2019.110786
dc.identifier.isiISI:000488146900031
dc.description.volume199
dc.contributor.orcid0000-0002-9100-4909
dc.contributor.orcid0000-0002-2830-3869
dc.contributor.orcid0000-0001-9657-1788
dc.contributor.orcid0000-0001-9299-0141
dc.contributor.orcid0000-0001-7815-4593
dc.contributor.orcid0000-0002-7229-5966
dc.contributor.researcheridAAF-2578-2020
dc.contributor.researcheridAAT-2667-2020
dc.contributor.researcheridK-7187-2019
dc.contributor.researcheridG-9021-2011
dc.identifier.eissn18733344
dc.publisher.placeSTE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
dcterms.isPartOf.abbreviationJ. Inorg. Biochem.
crisitem.author.deptInstitut für Chemie neuer Materialien-
crisitem.author.deptidinstitute11-
crisitem.author.parentorgFB 05 - Biologie/Chemie-
crisitem.author.grandparentorgUniversität Osnabrück-
crisitem.author.netidReHa636-
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