Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex
DC Element | Wert | Sprache |
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dc.contributor.author | Chmiest, Daniela | |
dc.contributor.author | Sharma, Nanaocha | |
dc.contributor.author | Zanin, Natacha | |
dc.contributor.author | de Lesegno, Christine Viaris | |
dc.contributor.author | Shafaq-Zadah, Massiullah | |
dc.contributor.author | Sibut, Vonick | |
dc.contributor.author | Dingli, Florent | |
dc.contributor.author | Hupe, Philippe | |
dc.contributor.author | Wilmes, Stephan | |
dc.contributor.author | Piehler, Jacob | |
dc.contributor.author | Loew, Damarys | |
dc.contributor.author | Johannes, Ludger | |
dc.contributor.author | Schreiber, Gideon | |
dc.contributor.author | Lamaze, Christophe | |
dc.date.accessioned | 2021-12-23T16:23:46Z | - |
dc.date.available | 2021-12-23T16:23:46Z | - |
dc.date.issued | 2016 | |
dc.identifier.issn | 20411723 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/14655 | - |
dc.description.abstract | Type-I interferons (IFNs) play a key role in the immune defences against viral and bacterial infections, and in cancer immunosurveillance. We have established that clathrin-dependent endocytosis of the type-I interferon (IFN-alpha/beta) receptor (IFNAR) is required for JAK/STAT signalling. Here we show that the internalized IFNAR1 and IFNAR2 subunits of the IFNAR complex are differentially sorted by the retromer at the early endosome. Binding of the retromer VPS35 subunit to IFNAR2 results in IFNAR2 recycling to the plasma membrane, whereas IFNAR1 is sorted to the lysosome for degradation. Depletion of VPS35 leads to abnormally prolonged residency and association of the IFNAR subunits at the early endosome, resulting in increased activation of STAT1-and IFN-dependent gene transcription. These experimental data establish the retromer complex as a key spatiotemporal regulator of IFNAR endosomal sorting and a new factor in type-I IFN-induced JAK/STAT signalling and gene transcription. | |
dc.description.sponsorship | Curie Institute; INSERMInstitut National de la Sante et de la Recherche Medicale (Inserm)European Commission; CNRSCentre National de la Recherche Scientifique (CNRS)European Commission; Agence Nationale de la RechercheFrench National Research Agency (ANR)European Commission [ANR MECANOCAV-12-BSV2-0011]; Institut National du CancerInstitut National du Cancer (INCA) France [INCa PLBIO12-203]; Marie Curie Actions-Networks for Initial Training [FP7-PEOPLE-2010-ITN]; Fondation pour la Recherche MedicaleFondation pour la Recherche Medicale; DFGGerman Research Foundation (DFG)European Commission [SFB 944]; The help of Dr Sentil Arumugam for image analysis is acknowledged. The facilities and technical assistance of members of the France-BioImaging national research infrastructure-PICT-IBiSA/Nikon Imaging Center at CNRS-Institut Curie, Paris, are acknowledged. This work was supported by institutional grants from the Curie Institute, INSERM, CNRS and by specific grants from Agence Nationale de la Recherche (ANR MECANOCAV-12-BSV2-0011 to C.L.), Institut National du Cancer (INCa PLBIO12-203 to C.L.), Marie Curie Actions-Networks for Initial Training (FP7-PEOPLE-2010-ITN to C.L. and D.C.), Fondation pour la Recherche Medicale to D. C. and DFG (SFB 944) to S.W. and J.P. The Johannes and Lamaze teams are members of Labex CelTisPhyBio Number ANR-10-LBX-0038 and part of the IDEX Idex PSL Number ANR-10-IDEX-0001-02 PSL. | |
dc.language.iso | en | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.relation.ispartof | NATURE COMMUNICATIONS | |
dc.subject | ACTIVATION | |
dc.subject | ALPHA | |
dc.subject | I INTERFERON | |
dc.subject | IFN-ALPHA-2 | |
dc.subject | IFNAR1 | |
dc.subject | IMPACT | |
dc.subject | Multidisciplinary Sciences | |
dc.subject | PROTEIN COMPLEXES | |
dc.subject | RECEPTOR | |
dc.subject | Science & Technology - Other Topics | |
dc.subject | SUBUNIT | |
dc.subject | UBIQUITINATION | |
dc.title | Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex | |
dc.type | journal article | |
dc.identifier.doi | 10.1038/ncomms13476 | |
dc.identifier.isi | ISI:000389183900001 | |
dc.description.volume | 7 | |
dc.contributor.orcid | 0000-0001-8468-3424 | |
dc.contributor.orcid | 0000-0002-2168-0004 | |
dc.contributor.orcid | 0000-0002-2168-0004 | |
dc.contributor.orcid | 0000-0002-7582-8131 | |
dc.contributor.orcid | 0000-0002-4112-710X | |
dc.contributor.orcid | 0000-0002-3062-3036 | |
dc.contributor.orcid | 0000-0002-9111-8842 | |
dc.contributor.orcid | 0000-0001-5430-2707 | |
dc.contributor.researcherid | T-8793-2017 | |
dc.contributor.researcherid | M-9778-2017 | |
dc.contributor.researcherid | W-8593-2019 | |
dc.contributor.researcherid | M-4912-2017 | |
dc.contributor.researcherid | G-5560-2017 | |
dc.publisher.place | MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND | |
dcterms.isPartOf.abbreviation | Nat. Commun. | |
dcterms.oaStatus | Green Published, gold | |
crisitem.author.dept | FB 05 - Biologie/Chemie | - |
crisitem.author.deptid | fb05 | - |
crisitem.author.orcid | 0000-0002-2143-2270 | - |
crisitem.author.parentorg | Universität Osnabrück | - |
crisitem.author.netid | PiJa938 | - |
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geprüft am 15.05.2024