Acne-associated syndromes: models for better understanding of acne pathogenesis

DC FieldValueLanguage
dc.contributor.authorChen, W.
dc.contributor.authorObermayer-Pietsch, B.
dc.contributor.authorHong, J-B
dc.contributor.authorMelnik, B. C.
dc.contributor.authorYamasaki, O.
dc.contributor.authorDessinioti, C.
dc.contributor.authorJu, Q.
dc.contributor.authorLiakou, A. I.
dc.contributor.authorAl-Khuzaei, S.
dc.contributor.authorKatsambas, A.
dc.contributor.authorRing, J.
dc.contributor.authorZouboulis, C. C.
dc.date.accessioned2021-12-23T16:23:51Z-
dc.date.available2021-12-23T16:23:51Z-
dc.date.issued2011
dc.identifier.issn09269959
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/14687-
dc.description.abstractAcne, one of the most common skin disorders, is also a cardinal component of many systemic diseases or syndromes. Their association illustrates the nature of these diseases and is indicative of the pathogenesis of acne. Congenital adrenal hyperplasia (CAH) and seborrhoea-acne-hirsutism-androgenetic alopecia (SAHA) syndrome highlight the role of androgen steroids, while polycystic ovary (PCO) and hyperandrogenism-insulin resistance-acanthosis nigricans (HAIR-AN) syndromes indicate insulin resistance in acne. Apert syndrome with increased fibroblast growth factor receptor 2 (FGFR2) signalling results in follicular hyperkeratinization and sebaceous gland hypertrophy in acne. Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) and pyogenic arthritis-pyoderma gangrenosum-acne (PAPA) syndromes highlight the attributes of inflammation to acne formation. Advances in the understanding of the manifestation and molecular mechanisms of these syndromes will help to clarify acne pathogenesis and develop novel therapeutic modalities.
dc.language.isoen
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
dc.subject13-CIS RETINOIC ACID
dc.subjectacne
dc.subjectANDROGEN EXCESS DISORDERS
dc.subjectApert syndrome
dc.subjectCONGENITAL ADRENAL-HYPERPLASIA
dc.subjectDermatology
dc.subjectHAIR-AN SYNDROME
dc.subjectinsulin resistance
dc.subjectOSTEITIS SAPHO SYNDROME
dc.subjectPAPA SYNDROME
dc.subjectPCO syndrome
dc.subjectPOLYCYSTIC-OVARY-SYNDROME
dc.subjectPYODERMA-GANGRENOSUM
dc.subjectPYOGENIC ARTHRITIS
dc.subjectSAPHO syndrome
dc.subjectSEBACEOUS GLAND
dc.titleAcne-associated syndromes: models for better understanding of acne pathogenesis
dc.typereview
dc.identifier.doi10.1111/j.1468-3083.2010.03937.x
dc.identifier.isiISI:000290533200002
dc.description.volume25
dc.description.issue6
dc.description.startpage637
dc.description.endpage646
dc.contributor.orcid0000-0003-1646-2608
dc.contributor.orcid0000-0001-9467-6463
dc.contributor.researcheridAAU-2952-2021
dc.contributor.researcheridI-4493-2013
dc.identifier.eissn14683083
dc.publisher.place111 RIVER ST, HOBOKEN 07030-5774, NJ USA
dcterms.isPartOf.abbreviationJ. Eur. Acad. Dermatol. Venereol.
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