Occupational UV-Exposure is a Major Risk Factor for Basal Cell Carcinoma: Results of the Population-Based Case-Control Study FB-181
Autor(en): | Schmitt, Jochen Haufe, Eva Trautmann, Freya Schulze, Hans-Joachim Elsner, Peter Drexler, Hans Bauer, Andrea Letzel, Stephan John, Swen Malte Fartasch, Manige Bruening, Thomas Seidler, Andreas Dugas-Breit, Susanne Gina, Michal Weistenhoefer, Wobbeke Bachmann, Klaus Bruhn, Ilka Lang, Berenice Mareen Bonness, Sonja Allam, Jean Pierre Grobe, William Stange, Thoralf Westerhausen, Stephan Knuschke, Peter Wittlich, Marc Diepgen, Thomas Ludwig FB 181 Study Grp |
Stichwörter: | BEHAVIORS; DISEASE; EPIDEMIOLOGY; LIGHT; NONMELANOMA SKIN-CANCER; PREVENTION; PROTECTION; Public, Environmental & Occupational Health; QUALITY-OF-LIFE; SUN EXPOSURE; YOUNG-ADULTS | Erscheinungsdatum: | 2018 | Herausgeber: | LIPPINCOTT WILLIAMS & WILKINS | Journal: | JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | Volumen: | 60 | Ausgabe: | 1 | Startseite: | 36 | Seitenende: | 43 | Zusammenfassung: | Objective:The aim of this study was to investigate the role of occupational and nonoccupational ultraviolet (UV)-exposure concerning the development of basal cell carcinoma (BCC).Methods:We undertook a population-based multicenter case-control study. Patients with first incident BCC (n=836) were propensity score matched by age and sex to controls without skin cancer (n=836). Sociodemographic characteristics, clinical characteristics, and lifetime UV-exposure were assessed by trained investigators. The differential estimation of occupational and nonoccupational UV-exposure dosages was based on validated instruments and established reference values. Associations were assessed using multivariable-adjusted conditional logistic regression models.Results:Individuals with high levels of occupational UV-exposure were at significantly increased BCC-risk compared with individuals with low [odds ratio (OR) 1.84; 95% confidence interval (95% CI) 1.19 to 2.83 and moderate (OR 1.97; 95% CI 1.20 to 3.22) occupational UV-exposure. Nonoccupational UV-exposure was not independently associated with BCC.Conclusion:Skin cancer prevention strategies should be expanded to the occupational setting. |
ISSN: | 10762752 | DOI: | 10.1097/JOM.0000000000001217 |
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geprüft am 29.05.2024