Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis
Autor(en): | Koppes, Sjors A. Engebretsen, Kristiane A. Agner, Tove Angelova-Fischer, Irena Berents, Teresa Brandner, Johanna Brans, Richard Clausen, Maja-Lisa Hummler, Edith Jakasa, Ivone Jurakic-Toncic, Ruzica John, Swen M. Khnykin, Denis Molin, Sonja Holm, Jan O. Suomela, Sari Thierse, Hermann-Josef Kezic, Sanja Martin, Stefan F. Thyssen, Jacob P. |
Stichwörter: | allergic contact dermatitis; Allergy; biomarkers; BOVINE SERUM-ALBUMIN; CHRONIC BERYLLIUM DISEASE; contact allergy; contact sensitization; CYTOKINE GENE POLYMORPHISMS; Dermatology; FILAGGRIN NULL MUTATIONS; GLUTATHIONE-S-TRANSFERASE; N-ACETYLTRANSFERASE 1; NATURAL MOISTURIZING FACTOR; NONANIMAL TEST METHODS; OF-FUNCTION MUTATIONS; SKIN BARRIER FUNCTION | Erscheinungsdatum: | 2017 | Herausgeber: | WILEY | Journal: | CONTACT DERMATITIS | Volumen: | 77 | Ausgabe: | 1 | Startseite: | 1 | Seitenende: | 16 | Zusammenfassung: | Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described. |
ISSN: | 01051873 | DOI: | 10.1111/cod.12789 |
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geprüft am 01.06.2024