Evolutionary origins of membrane proteins

Autor(en): Mulkidjanian, A.Y.
Galperin, M.Y.
Erscheinungsdatum: 2010
Herausgeber: Springer Vienna
Journal: Structural Bioinformatics of Membrane Proteins
Startseite: 1
Seitenende: 28
Although the genes that encode membrane proteins make about 30% of the sequenced genomes, the evolution of membrane proteins and their origins are still poorly understood. Here we address this topic by taking a closer look at those membrane proteins the ancestors of which were present in the Last Universal Common Ancestor, and in particular, the F/V-type rotating ATPases. Reconstruction of their evolutionary history provides hints for understanding not only the origin of membrane proteins, but also of membranes themselves. We argue that the evolution of biological membranes could occur as a process of coevolution of lipid bilayers and membrane proteins, where the increase in the ion-tightness of the membrane bilayer may have been accompanied by a transition from amphiphilic, pore-forming membrane proteins to highly hydrophobic integral membrane complexes. © 2010 Springer-Verlag Vienna.
ISBN: 9783709100448
DOI: 10.1007/978-3-7091-0045-5_1
Externe URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859452614&doi=10.1007%2f978-3-7091-0045-5_1&partnerID=40&md5=14f65fbb235722584490b7a2824f5b7a

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