Wavefront-obstacle and wavefront-wavefront interactions as mechanisms for atrial fibrillation: A study based on the FitzHugh-Nagumo equations

Autor(en): Lenk, C.
Einax, M.
Maass, P. 
Stichwörter: Atrial fibrillation; Fitzhugh-Nagumo equations; Generating mechanism; Numerical solution; Perturbation frequency; Re-entrant waves; Shannon entropy; Spatiotemporal characteristics; Wave changes, Cardiology; Diseases; Reentry, Wavefronts
Erscheinungsdatum: 2010
Journal: Computing in Cardiology
Volumen: 37
Startseite: 425
Seitenende: 428
Zusammenfassung: 
We investigate generating mechanisms of atrial fibrillation (AF) based on numerical solutions of the FitzHugh- Nagumo equations. In particular, the interaction of reentrant wavefronts with obstacles, modeled as tissue with gradually reduced excitability, is presented. We show that with increasing modification strength, the spatio-temporal characteristics of the wave changes from functional to anatomical reentry. With decreasing distance of the obstacle to a non-conducting boundary, a transition is observed from a stable spiral to a transient reentrant wave with two to three reentries up to a suppression of reentries. We further study the possibility to generate irregular, fibrillatory patterns by the perturbation of regularly paced waves by a second pacemaker. The irregularity depends on the perturbation frequency and the geometry of the simulation area and is quantified in terms of a Shannon entropy.
Beschreibung: 
Conference of Computing in Cardiology 2010, CinC 2010 ; Conference Date: 26 September 2010 Through 29 September 2010; Conference Code:84517
ISBN: 9781424473182
ISSN: 23258861
Externe URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953835964&partnerID=40&md5=7a38231fd323007f4e608ff48d5e5fbb

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