Two channel microfluidic CARS for quantifying pure vibrational contrast of model analytes

Autor(en): Dietzek, B.
Bergner, G.
Akimov, D.
Malsch, D.
Henkel, T.
Schlücker, S.
Popp, J.
Stichwörter: Analytes; Analytical method; Analytical methods; Coherent anti-Stokes Raman; Coherent anti-stokes raman microscopy; Deuterium; Experimental design; Health care; Internal standards; Isotopomers; Microfluidic chip; Microfluidics; Nonresonant; Nonresonant background; Organic molecules; Quantitative detection; Raman scattering; Raman spectroscopy; Raman spectroscopy, Microfluidics; Relative contribution; Resonant signal; Simultaneous measurement; Two-channel; Versatile tools, Coherent scattering
Erscheinungsdatum: 2010
Journal: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volumen: 7715
We discuss the combination of a CARS-imaging system with microfluidics. Such system is a versatile tool to quantify the relative contributions of resonant and non-resonant scattering at the CARS frequency. We will show that the twochannel microfluidic chip employed in combination with deuterated isotopomers as an internal standard allows for fast and quantitative detection of organic molecules by CARS microscopy. The experimental design enables the simultaneous measurement of both the chemically relevant Raman-resonant signal and the non-Raman-resonant background. © 2010 SPIE.
Conference of Biophotonics: Photonic Solutions for Better Health Care II ; Conference Date: 12 April 2010 Through 16 April 2010; Conference Code:83558
ISBN: 9780819481887
ISSN: 16057422
DOI: 10.1117/12.853843
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